basic FUNCTION
| palmitoylated phosphoprotein that can attenuate or potentiate numerous growth factor-induced signaling pathways inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway |
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inhibitor for receptor tyrosine kinase signaling cascades, such as those of FGF receptor family members and EGF receptor family members |
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both redundant and non-redundant functions for SPRY2 and SPRY4 on embryonic development and FGF signaling |
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suppressing cell spreading by inhibiting the kinase activity of TESK1 |
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having a cellular function to regulate the actin cytoskeleton, independent of its inhibitory activity on the Ras/MAP kinase signalling |
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selectively suppresses Ras-independent angiogenic factor signals and is an important negative regulator of pathophysiological angiogenesis |
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inhibites the PKC pathway, suppressing various signals downstream of PKC, such as phosphorylation of MARCKS and PKD |
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also supressing upstream signals of PKC such as Ca2+ mobilization, PIP2 breakdown and IP3 production in response to VEGF-A |
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might be involved in the timely restriction of MAPK signals under hypoxic conditions, similar to its role in mitogen-regulated processes |
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SPRY1, SPRY2, SPRY3, SPRY4, are central and complex regulators of the receptor tyrosine kinase (RTK) signalling pathway |
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regulates angiogenesis in part by regulating endothelial cell migration |
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unanticipated role for SPRY4 in regulating SRC activity and ITGB3 protein levels, which contributes to the regulation of migration and adhesion of endothelial cells |