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FLASH GENE
Symbol DMRTA1 contributors: mct - updated : 03-04-2018
HGNC name DMRT-like family A1
HGNC id 13826
Location 9p21.3      Physical location : 22.446.839 - 22.452.472
Synonym symbol(s) DMO, HGNC13828, DMRT4
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 5.63 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 2302 - 504 - 2009 19274049
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a doublesex DM DNA binding domain
HOMOLOGY
interspecies homolog to Drosophila master sex regulator gene,doublesex
Homologene
FAMILY DMRT
CATEGORY regulatory , transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION unknown
CELLULAR PROCESS nucleotide, transcription, regulation
PHYSIOLOGICAL PROCESS development
text sex differentiation
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA binding
RNA
small molecule
protein
  • FOXG1 binds to mammalian-specific noncoding sequences to repress over 12 transcription factors expressed in early progenitors, including EBF2/3, DMRT3, DMRTA1, and EYA2
  • overexpression of DMRTA1 induced the expression of the proneural gene Neurogenin2 (NEUROG2) and conversely repressed ASCL1, a proneural gene expressed in the ventral telencephalon
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • type 2 diabetes (T2D)
    • Variant & Polymorphism other rs1575972 near DMRTA1 is linked to type 2 diabetes
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS