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FLASH GENE

Symbol

ITGB5

contributors: npt/ - updated : 28-11-2005

HGNC name	integrin, beta 5
HGNC id	6160

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	3q21.2      Physical location : 124.481.795 - 124.606.144
Synonym symbol(s)	EVI129, FLJ26658

DNA

TYPE	functioning gene
STRUCTURE	124.35 kb     15 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed ITGB5 15 - 3392 88 799 - -

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas       highly Lymphoid/Immune spleen       highly Respiratory lung       highly Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		Hydrophobic
STRUCTURE

motifs/domains	one VWPA-like domain
	a signal peptide (hydrophobic leader sequence)
	an extracellular domain with8 N-glycosylation sites
	one VWPA-like domain,four cystein-rich tandem repeats
	a transmembrane domain
	a cytoplasmic domain

conjugated

GlycoP

mono polymer

heteromer , dimer

isoforms

Precursor

HOMOLOGY

interspecies	ortholog to murine itgb5
	homolog to Drosophila mys
	homolog to C.elegans pat-3

Homologene

FAMILY

integrin beta chain family

CATEGORY

adhesion , signaling , receptor

SUBCELLULAR LOCALIZATION	plasma membrane
text	type I membrane protein

basic FUNCTION

involved in cell-extracellular adhesion and cell-cell-adhesion

CELLULAR PROCESS

cell communication

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

ITGAV and ITGB5

INTERACTION

DNA

RNA

small molecule

protein	binding to betaig-h3 by an YH motif peptide
	binding to fibronectin and vitronectin

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS