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FLASH GENE
Symbol APOBEC3D contributors: mct - updated : 18-12-2017
HGNC name apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D
HGNC id 17354
Location 22q13.1      Physical location : 39.417.117 - 39.429.255
Synonym name
  • apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D (putative)
  • DNA dC->dU-editing enzyme APOBEC-3D
  • apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3E pseudogene
  • apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D (putative)
  • Synonym symbol(s) APOBEC3E, ARP6, APOBEC3DE
    EC.number 3.5.4.-
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 12.14 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2519 46 386 - Dang (2006)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen    
    Nervousbrain    
    Respiratorylung    
    cell lineage
    cell lines colorectal adenocarcinoma cells and chronic myelogenous leukemia cells
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • cytidine and deoxycytidylate deaminase family
  • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • contributor to the intracellular defense network, resulting in suppression of retroviral invasion
  • APOBEC3 proteins function within the innate immune system by mutating DNA of viral genomes and retroelements to restrict infection and retrotransposition
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS