Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CSNK1D contributors: mct - updated : 04-05-2007
HGNC name casein kinase 1, delta
HGNC id 2452
Corresponding disease
FASPS2 familial advanced sleep phase syndrome 2
Location 17q25.2-q25.3      Physical location : 80.202.241 - 80.231.573
Synonym name serine threonine kinase isoform D
Synonym symbol(s) CK1D, HCKID
EC.number 2.7.1.-, 2.7.11.1
DNA
TYPE functioning gene
STRUCTURE 29.00 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 2030 47.3 415 - Li
- - 2106 - 409 - Li
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus   highly
Nervousbrain   highly
Reproductivemale systemtestis  highly
Visualeye   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a kinase domain
mono polymer monomer
HOMOLOGY
interspecies ortholog to yeast S.cerevisiae ck1hrr25
ortholog to yeast S.pombe ck1
Homologene
FAMILY serine/threonine protein kinase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nuclear envelope
text
  • cell surface receptor linked
  • localized in close proximity in the perinuclear region
  • basic FUNCTION
  • central component in the mammalian clock
  • casein kinase 1, catalytic unit, delta 1, involved in the transduction of WNT signal
  • central component in the clock
  • playing an important role in the mitotic progression and in the survival of cells of trophoblast
  • CELLULAR PROCESS nucleotide, repair
    PHYSIOLOGICAL PROCESS
    text
  • by homology, putatively involved in DNA repair through excision and recombination
  • PATHWAY
    metabolism
    signaling
  • putatively involved in DNA repair through excision and recombination
  • a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP
    protein
  • preferentially acidic proteins, broad specificity
  • interacting with SNAPIN (possible function in modulating snapin specific functions)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) FASPS2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS