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FLASH GENE
Symbol ACTR3B contributors: - updated : 05-12-2005
HGNC name ARP3 actin-related protein 3 homolog B (yeast)
HGNC id 17256
Location 7q34-36      Physical location : 152.456.850 - 152.552.463
Synonym name
  • actin-related protein Arp11
  • actin-related protein 3-beta
    • Synonym symbol(s) ARP11, ARP3BETA
    DNA
    TYPE functioning gene
    STRUCTURE 95.00 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    regionally located centromeric to SHH
    RNA
    TRANSCRIPTS type messenger
    text alternative splicing resulting in exon skipping and leading to truncated proteins, several truncated forms
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   lowly
    Endocrinepancreas    
    Nervousbrain   highly
     plexus choroid    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscular    
    Nervouscentral   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines low metastatic PC14 lung adenocarcinoma cells lineage
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		actin domain
    HOMOLOGY
    intraspecies homolog to ARP3
    Homologene
    FAMILY actin related family ARP3
    CATEGORY regulatory , structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • development and/or maintenance of distinct substes of nerve cells
  • regulator of the level of the platelet activating factor (PAF) in the brain
    • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein actin
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS