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FLASH GENE

Symbol

CCL28

contributors: npt/ - updated : 19-11-2005

HGNC name	chemokine (C-C motif) ligand 28
HGNC id	17700

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	5p12      Physical location : 43.381.600 - 43.412.488
Synonym name	mucosae-associated epithelial chemokine
	small inducible cytokine subfamily A (Cys-Cys), member 28
	mammary enriches chemokine
	protein CCK1
Synonym symbol(s)	SCYA28, MEC, CCK1, MGC71902

DNA

TYPE	functioning gene
STRUCTURE	30.89 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed SCYA28-V1 - splicing 800 14.3 127 prostate, colon, spleen, peripheral blood leukocytes, epithelial cells of colon Wang same isoform than SCYA28 differing in the 3' UTR sequence SCYA28 - splicing 1300 14.3 127 - Wang same isoform than SCYA28-V1 SCYA28-V2 - splicing 6000 - - prostate,colon,spleen,preipheral blood leukocytes,epithelial cells of colon Wang

EXPRESSION

Type

widely

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       predominantly Digestive intestine large intestine colon   predominantly   intestine large intestine rectum       intestine small intestine         salivary gland           stomach       lowly Endocrine thyroid         Reproductive female system breast         male system prostate     predominantly Respiratory respiratory tract trachea     highly Skin/Tegument skin         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Connective bone       digestive intestine Peyer's patches     Epithelial barrier/lining       Epithelial secretory glandular endocrine   Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte Digestive epithelial cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	twenty two AA N terminal signal peptide
	six cysteines residues
	long C terminal tail

conjugated

GlycoP

HOMOLOGY

interspecies	homolog to murine Scya28
	homolog to C.elegans F13H8.9

intraspecies

homolog to CCL27

Homologene

FAMILY	small cytokine CC genes subfamily
	intercrine beta family

CATEGORY

signaling cytokine

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	inducing calcium mobilization in a dose-dependent manner
	may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs
	displaying chemotactic activity for resting CD4 or CD8 T cells and eosinophils

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense , inflammation

text	immunoregulatory and inflammatory processes

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

binding to receptors CCR3 and CCR10/GPR2

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in epithelioid tumor cell lines tumoral     --low   or absent in breast tumor

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS