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FLASH GENE

Symbol

PRKCH

contributors: mct - updated : 15-03-2011

HGNC name	protein kinase C, eta
HGNC id	9403

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006255 14 - 3522 - 683 - 1999 10497222

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       lowly Digestive mouth       highly   pharynx       highly Lymphoid/Immune thymus       highly Respiratory lung       highly Skin/Tegument skin       lowly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier/lining

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument keratinocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two zinc-dependent phorbol-ester and Dag binding C1 domain
	a C1b domain sufficient for translocation to the nuclear envelope, and that could also confer protection against etoposide-induced cell death
	one C2, a consensus ATP-binding site, a catalytic kinase
	a conserved cysteine-rich domains
	a PIF domain
	a Golgi luminal domain is potentially the major functional domain
	a protein kinase domain

HOMOLOGY

interspecies

homolog to C.elegans fs7f5.5

Homologene

FAMILY

serine/threonine kinase family, PKC subfamily

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,cytosolic
	intracellular,nuclear envelope
text	epithelial specific isoform, localized at the cytoplasm and ER/Golgi
	translocation to the nuclear envelope, and its spatial regulation could be important for its cellular functions including effects on cell death

basic FUNCTION	calcium-independent and phospholipids-dependent protein kinase, mediating the transcription activation of the transglutaminase 1 (TGM1) gene
	having cellular functions including effects on cell cycle control and involvement in tumor promotion, regulated by translocation to the nuclear envelope
	mediates glioblastoma cell proliferation through the Akt and MTOR signaling pathways
	regulates occludin phosphorylation and epithelial tight junction integrity
	positively regulates agonist-induced thromboxane generation with no effects on platelet aggregation
	confers protection against apoptosis induced by the DNA damaging agents, UVC irradiation and the anti-cancer drug--Camptothecin
	anti-apoptotic protein, acting as a negative regulator of JNK activity
	play important roles in cell proliferation, differentiation, apoptosis, migration and tumorigenesis
	increased JUND in keratinocytes
	with PRKCD, differently regulate the expression of loricrin and Jun family proteins in keratinocytes
	is important for TLR2-mediated ABCA1 expression

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	FEZ1
	intercting with CEBPA and MAPK13 (can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA))
	activation of PRKCH and PLD2 signaling pathway is an important mechanism for regulation of TLR2-induced ABCA1 expression

cell & other

REGULATION

activated by

lipids

induced by

EFHD2 (PRKCB1/PRKCH-inducible gene that modulates mast cell activation through NF-kappaB-dependent pathway

Other

regulated at the translational level both under normal growth conditions and during stress imposed by amino acid starvation, the latter causing a marked increase in its protein levels

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in hepatocellular carcinoma, and may represent a molecular lesion in the development of more aggressive form

Susceptibility

to cerebral lacunar infarction to rheumatoid arthritis

Variant & Polymorphism SNP	-rs3783799 and rs2230500 increasing the risk of cerebral silent lacunar infarction
	could be associated with the patho-physiologic mechanism of rheumatoid arthritis

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     could represent a target for intervention aimed to reduce resistance to anti-cancer treatments

ANIMAL & CELL MODELS