| basic FUNCTION
| guanine nucleotide releasing factor, specific for Ras proteins |
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regulating postnatal growth through synthesis or release of growth hormone |
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with ARHGAP5, control pivotal aspects of neural development, including neuronal differentiation and process outgrowth  |
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neuron-specific guanine nucleotide exchange factor for the small GTPases RAS and RAC1 |
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RASGRF1 and ARHGAP5 function to modulate Rho signaling in response to integrin engagement |
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proper neonatal RASGRF1 expression levels are critical for development |
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central role in governing striatal adaptations to dopamine replacement therapy, validating a viable treatment for L-dopa-induced dyskinesia (LID) based on intracellular signaling modulation |
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RASGRF1 and ARHGAP5 are essential genes that have distinct, but overlapping roles in the developing nervous system |
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its function in both the epithelium and stroma is required for mammary gland development |
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is potentially required in both the epithelial and stromal compartments for ductal outgrowth and may play a role in mammary epithelial cell differentiation |
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plays an important role in alveolar rhabdomyosarcomas pathogenesis |
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RASGRF1 and -GRF2 may act as adaptors that bind PLCG1 and restrict Ca2+ signalling to the vicinity of focal adhesions, indicating a new role for these GRFs that is required for IL1 induction of the RAS& |
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8594;ERK pathway and MMP3 expression |
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could mediate forms of synaptic plasticity and might participate in the regulation of neuronal excitability and neurite outgrowth though various signal transduction pathway |
