Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

ARC

contributors: mct/pgu - updated : 16-02-2013

HGNC name	activity-regulated cytoskeleton-associated protein
HGNC id	648

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_015193 3 - 2985 NP_056008 45 396 - 2011 22036569

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain limbic system hippocampus dentate gyrus   Homo sapiens Adult Reproductive male system prostate       Respiratory lung

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

ARC/ARG3.1 family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,endosome
	intracellular,cytoplasm,cytoskeleton
	intracellular,nucleus
text	present exclusively in the postsynaptic compartment

basic FUNCTION	comodulator with FB1 of cell death in brain
	required for the late-phase of long-term potentiation (LTP) and memory consolidation, and has been implicated in AMPA receptor trafficking
	required for multiple forms of synaptic plasticity that depend on its endocytic function including homeostatic scaling
	first target of serum response factor that functions at synapses to mediate plasticity
	functions as a spectrin-binding protein, forming a complex that may provide a role at sites of transcriptional regulation within the nucleus
	synaptic protein that promotes the internalization of the AMPA subtype of glutamate receptors
	PDGF-mediated induction of ARC involved activation of the MAPK/ERK (MEK) pathway
	effector immediate-early gene rapidly induced by strong neural activity
	functional rolein memory reconsolidation processes in the mammalian brain
	required for activity-dependent generation of APP
	role in postsynaptic trafficking and processing of APP that appears relevant to the pathogenesis of Alzheimer disease
	potentially functioning to increase gamma-secretase in dendritic trafficking endosomes that process APP
	critically contributes to weakening synapses by promoting AMPAR endocytosis
	essential roles both for the late phase of long-term plasticity and for reduction of surface AMPA-Rs in stimulated neurons
	crucial mediator for actin polymerization functions

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacts with SH3GL1/endophilin-2, SH3GL3/endophilin-3 and DNM2
	neuron-specific, postsynaptic protein that interacts with endophilin and dynamin and contributes to an endocytic pathway that accelerates removal of AMPA receptors from excitatory synapses
	interacting with UBE3A (UBE3A regulates excitatory synapse development by controlling the degradation of ARC)
	neuronal NOTCH1 signaling is positively regulated by ARC, an activity-induced gene required for synaptic plasticity
	physically associates with presenilin1 (PSEN1) to regulate gamma-secretase trafficking and confer activity dependence
	ARC and PSEN1 directly and specifically interact
	activation of intracellular GRM5 also up-regulates genes involved in synaptic plasticity including activity-regulated cytoskeletal-associated protein (ARC)

cell & other

REGULATION

induced by

specific patterns of synaptic activity

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --other   ARC expression is maintained at normal or supranormal levels in a brain area impacted by AD, and thus could contribute to APP generation and pathology

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS