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FLASH GENE
Symbol CETP contributors: mct - updated : 08-04-2022
HGNC name cholesteryl ester transfer protein, plasma
HGNC id 1869
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • a signal peptide
  • a N terminal half with a LPS binding site
  • a conserved C terminal, required for anchoring lipoprotein particles
    • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to LBP,low
    Homologene
    FAMILY
  • BPI/LBP family
  • BPI/LBP/Plunc superfamily
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol
  • playing a key role in the determination of high-density lipoprotein (HDL) levels via its action on intravascular HDL metabolism
  • role of PLTP and CETP in atherogenesis
  • anti-adipogenic role for CETP
  • CETP might be a limiter of reverse cholesterol transport and HDL maturation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • mediates the exchange of cholesteryl ester for triglycerides between HDL and VLDL and LDL
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CETPD
    Susceptibility
  • to coronary heart disease and carotid atherosclerosis
  • to exceptional longevity (Barzilai 06)
  • HDL cholesterol level QTL10 (Spirin 07)
  • the development of retinopathy of prematurity (ROP)
  • to age-related macular degeneration
  • to metabolic syndrome
  • to intracerebral hemorrhage (ICH)
    • Variant & Polymorphism SNP , other
  • taq1 B2B2 protective against coronary heart disease (associated with higher levels of plasma HDL-C )
  • functional interaction between -629C/A, -971G/A and -1337C/T polymorphisms is a major determinant of promoter activity and plasma CETP concentration(and HDL levels)
  • association between SNPs and the development of ROP
  • association of variants with age-related macular degeneration (Chen 2010)
  • CETP rs820299 is associated with metabolic syndrome
  • Genetic variants in CETP associated with increased HDL-C raise the risk of ICH
    • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabetemetabolic syndrom 
    CETP inhibitors could have a significant impact in the management of dyslipidemic CHD patients
    ANIMAL & CELL MODELS
    not contributing to the generation of prebeta-HDL in transgenic mice