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FLASH GENE

Symbol

CETP

contributors: mct - updated : 08-04-2022

HGNC name	cholesteryl ester transfer protein, plasma
HGNC id	1869

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000078 16 - 1717 NP_000069 53.1 493 - 2021 34609279 FL-CETP E9-deleted CETP, like FL-CETP, alters cellular TG metabolism and storage but in a contrary manner NM_001286085 15 - 1511 NP_001273014 - 433 - 2021 34609279 E9-deleted CETP 15 - - - - E9-deleted CETP is not secreted 2020 31988147 lacking exon 9 E9-deleted CETP, like FL-CETP, alters cellular TG metabolism and storage but in a contrary manner

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen         Digestive intestine small intestine         liver         Endocrine adrenal gland         Nervous brain         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose       Connective cartilage       Epithelial secretory glandular endocrine   Lymphoid

cell lineage	in and throughout differentiation of preadipocyte
cell lines
fluid/secretion	plasma

at STAGE

PROTEIN

PHYSICAL PROPERTIES		Hydrophobic
STRUCTURE

motifs/domains	a signal peptide
	a N terminal half with a LPS binding site
	a conserved C terminal, required for anchoring lipoprotein particles

conjugated

GlycoP

HOMOLOGY

intraspecies

homolog to LBP,low

Homologene

FAMILY	BPI/LBP family
	BPI/LBP/Plunc superfamily

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol
	playing a key role in the determination of high-density lipoprotein (HDL) levels via its action on intravascular HDL metabolism
	role of PLTP and CETP in atherogenesis
	anti-adipogenic role for CETP
	CETP might be a limiter of reverse cholesterol transport and HDL maturation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

lipid/lipoprotein

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

mediates the exchange of cholesteryl ester for triglycerides between HDL and VLDL and LDL

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CETPD

Susceptibility

to coronary heart disease and carotid atherosclerosis to exceptional longevity (Barzilai 06) HDL cholesterol level QTL10 (Spirin 07) the development of retinopathy of prematurity (ROP) to age-related macular degeneration to metabolic syndrome to intracerebral hemorrhage (ICH)

Variant & Polymorphism SNP , other	taq1 B2B2 protective against coronary heart disease (associated with higher levels of plasma HDL-C )
	functional interaction between -629C/A, -971G/A and -1337C/T polymorphisms is a major determinant of promoter activity and plasma CETP concentration(and HDL levels)
	association between SNPs and the development of ROP
	association of variants with age-related macular degeneration (Chen 2010)
	CETP rs820299 is associated with metabolic syndrome
	Genetic variants in CETP associated with increased HDL-C raise the risk of ICH

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed diabete metabolic syndrom   CETP inhibitors could have a significant impact in the management of dyslipidemic CHD patients

ANIMAL & CELL MODELS

not contributing to the generation of prebeta-HDL in transgenic mice