Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol LHX3 contributors: mct - updated : 31-05-2014
HGNC name LIM homeobox 3
HGNC id 6595
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two amino terminal tandemly repeated LIM motifs
  • three homeodomains
  • a C terminus helix-turn-helix (homeodomain) binding protein, carboxyl activation domain
    • mono polymer tetramer
    HOMOLOGY
    interspecies ortholog to murine Lhx3
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • LIM homeodomain class transcription factors with important roles in pituitary and nervous system development
  • play essential roles in pituitary gland and nervous system development
  • transactivator of pituitary genes
  • required for the function of both motoneuron and interneuron complex in presence of ISL1 and LDB1
  • involved in activation of the FSH beta-subunit gene in the pituitary gonadotrope cell, via its LIM homeodomain
  • required for cochlea hair cell differentiation and is regulated in part either directly or indirectly by POU4F3 specifically in the cochlea sensory epithelium
  • essential for pituitary gland and nervous system development
  • LHX3/VSX2 medullary reticular formation neurons are likely involved in locomotion
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    text pituitary development
    PATHWAY
    metabolism
    signaling
    a component
  • tetramer with LDB1-ISL1
  • LIM complex composed of ISL1 and LHX3 directs the specification of spinal motor neurons (MNs) in embryos
  • crucial regulatory axis for the ventral axonal trajectory of developing spinal MNs, consisting of the ISL1-LHX3 complex, STAM1 and CXCR4
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • isoform a coinducing TSGB with POU1F1
  • isoform b transactivating the alpha-glyco protein subunit (CGA) promoter
  • LDB1-ISL1 (by the LIM domain)
  • SLB
  • possible interaction between LHX3 and SOX2 likely to be important for development of both the inner ear and the anterior pituitary in embryonic development (SOX2 is able to activate transcription of the LHX3 promoter)
  • ISL1 is a novel transcriptional regulator of LHX3
    • cell & other
    REGULATION
    Other expression of LHX3 is regulated differently in auditory and vestibular hair cells
    ASSOCIATED DISORDERS
    corresponding disease(s) CPHD3
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    cooperating with Lhx4 in pituitary development in mice