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FLASH GENE
Symbol HUNK contributors: mct - updated : 24-12-2009
HGNC name hormonally upregulated Neu-associated kinase
HGNC id 13326
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • SNF1 homology domain (SNH)
  • a 260-AAs domain predicted to have serine/threonine kinase activity
    • HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • CAMK Ser/Thr protein kinase family
  • Snf1/AMPK family of kinases
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    text nucleocytoplasmic distribution and is localized to the centrosome, as indicated by co-localization with gamma-tubulin
    basic FUNCTION
  • could be regulating exocytosis and involved in disorders of the nervous system, development or in malignancies
  • involved in mammary development and carcinogenesis in mouse, SNF1-related
  • possible involvement in proliferative suppression of renal tubular cells
  • nuclear and centrosomal targeting is specific, and is likely to be coupled to its catalytic activity
  • may contribute to changes in the mammary gland that occur during pregnancy in response to ovarian hormones
  • its kinase activity is required for mammary tumor cells to gain access to the circulation and metastasize
  • metastasis suppressor for the basal breast cancer subtype
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with Rabaptin-5, a protein which plays an important role in endocytosis
  • disrupts the ability of PPP2R4 to bind to CFL1 while sparing its capacity to bind to other substrates such as ERK or AKT
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in aggressive subsets of carcinomas of the ovary, colon, and breast
    constitutional     --over  
    sustained the constitutive phosphorylation and inactivation of cofilin-1 (CFL1), thereby blocking the incorporation of new actin monomers into actin filaments
    tumoral     --low  
    is necessary for basal cancer cell metastasis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target target for anti-neoplastic therapy
    ANIMAL & CELL MODELS