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FLASH GENE
Symbol HUNK contributors: mct - updated : 24-12-2009
HGNC name hormonally upregulated Neu-associated kinase
HGNC id 13326
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in aggressive subsets of carcinomas of the ovary, colon, and breast
constitutional     --over  
sustained the constitutive phosphorylation and inactivation of cofilin-1 (CFL1), thereby blocking the incorporation of new actin monomers into actin filaments
tumoral     --low  
is necessary for basal cancer cell metastasis
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target target for anti-neoplastic therapy
ANIMAL & CELL MODELS