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FLASH GENE

Symbol

HUNK

contributors: mct - updated : 24-12-2009

HGNC name	hormonally upregulated Neu-associated kinase
HGNC id	13326

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	130.75 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014586 11 - 7385 NP_055401 80 714 - 2000 10662544

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system breast mammary gland     Homo sapiens Urinary kidney tubule Henles loop HL ascending limb     kidney tubule convoluted tubule distal tubule   Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central       Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	mammary gland, central nervous system, distal conoluted tubule, ascending limbs

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	SNF1 homology domain (SNH)
	a 260-AAs domain predicted to have serine/threonine kinase activity

HOMOLOGY

Homologene

FAMILY	protein kinase superfamily
	CAMK Ser/Thr protein kinase family
	Snf1/AMPK family of kinases

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
	intracellular,nucleus
text	nucleocytoplasmic distribution and is localized to the centrosome, as indicated by co-localization with gamma-tubulin

basic FUNCTION	could be regulating exocytosis and involved in disorders of the nervous system, development or in malignancies
	involved in mammary development and carcinogenesis in mouse, SNF1-related
	possible involvement in proliferative suppression of renal tubular cells
	nuclear and centrosomal targeting is specific, and is likely to be coupled to its catalytic activity
	may contribute to changes in the mammary gland that occur during pregnancy in response to ovarian hormones
	its kinase activity is required for mammary tumor cells to gain access to the circulation and metastasize
	metastasis suppressor for the basal breast cancer subtype

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacts with Rabaptin-5, a protein which plays an important role in endocytosis
	disrupts the ability of PPP2R4 to bind to CFL1 while sparing its capacity to bind to other substrates such as ERK or AKT

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in aggressive subsets of carcinomas of the ovary, colon, and breast constitutional     --over   sustained the constitutive phosphorylation and inactivation of cofilin-1 (CFL1), thereby blocking the incorporation of new actin monomers into actin filaments tumoral     --low   is necessary for basal cancer cell metastasis

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	target for anti-neoplastic therapy

ANIMAL & CELL MODELS