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FLASH GENE

Symbol

FOSL1

contributors: mct/npt/shn - updated : 04-12-2012

HGNC name	FOS-like antigen 1
HGNC id	13718

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in breast cancer in progression tumoral     --over   in pancreatic cancer tumoral     --low   in non-small-cell lung cancer with poor survival (Ma 2009)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	target for therapeutic interventions in malignant gliomas
	gene ablation can suppress the invasive phenotypes of many tumor cell lines
	potentially useful in pancreatic tumor targeting or as tumor markers
	lethality of fra-1-knockout mice can be rescued by specific deletion of Fra-1 only in the mouse embryo
	autoregulatory loop between JUN and FOSL1 might represent an important determinant for the increased JUN activity and a novel target for therapeutic intervention in tumorigenesis

ANIMAL & CELL MODELS

	Ectopic expression of the transcription factor Fra-1 in transgenic mice leads to osteosclerosis
	fra-1-knockout mice die in utero likely due to placental defects
	Mice lacking Fra-1 (fra-1(delta/delta)) are viable and develop osteopenia, a low bone mass disease