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FLASH GENE
Symbol FOSL1 contributors: mct/npt/shn - updated : 04-12-2012
HGNC name FOS-like antigen 1
HGNC id 13718
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in breast cancer in progression
tumoral     --over  
in pancreatic cancer
tumoral     --low  
in non-small-cell lung cancer with poor survival (Ma 2009)
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
  • target for therapeutic interventions in malignant gliomas
  • gene ablation can suppress the invasive phenotypes of many tumor cell lines
  • potentially useful in pancreatic tumor targeting or as tumor markers
  • lethality of fra-1-knockout mice can be rescued by specific deletion of Fra-1 only in the mouse embryo
  • autoregulatory loop between JUN and FOSL1 might represent an important determinant for the increased JUN activity and a novel target for therapeutic intervention in tumorigenesis
  • ANIMAL & CELL MODELS
  • Ectopic expression of the transcription factor Fra-1 in transgenic mice leads to osteosclerosis
  • fra-1-knockout mice die in utero likely due to placental defects
  • Mice lacking Fra-1 (fra-1(delta/delta)) are viable and develop osteopenia, a low bone mass disease