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FLASH GENE

Symbol

ROR2

contributors: shn/ - updated : 24-06-2018

HGNC name	receptor tyrosine kinase-like orphan receptor 2
HGNC id	10257

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

BDB1 , DEL9Q22 , RBNS

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   hypoxia-inducible factor target in von hippel-Lindau-associated RCC

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     WNT5a-ROR2 signaling can be a target of cancer therapies to prevent cancer cells from undergoing invasion and metastasis cancer brain glioma/neuroblstoma ROR1 and ROR2 could serve as novel targets for immunotherapy in neuroblastoma cancer reproductive ovary targeting both ROR1 and ROR2 may be a powerful approach to treating ovarian cancer

ANIMAL & CELL MODELS

	Disruption of mouse Ror2 leads to profound skeletal abnormalities with essentially all endochondrally derived bones foreshortened or misshapen
	Ror2-deficient mice had cardiac septal defects and skeletal abnormalities, including shorter limbs, vertebrae, and facial structure, with a particular defect in their distal portions and died after birth
	Ror1/Ror2 double-mutant mice showed skeletal abnormalities including a sternal defect and dysplasia of the symphysis of the pubic bone