| 1 | ROR1, ROR2
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| The Cell Surface Receptors Ror1/2 Control Cardiac Myofibroblast Differentiation.
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| Chavkin NW, Sano S, Wang Y, Oshima K, Ogawa H, Horitani K, Sano M, MacLauchlan S, Nelson A, Setia K, Vippa T, Watanabe Y, Saucerman JJ, Hirschi KK, Gokce N, Walsh K.
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| J Am Heart Assoc. Jul 6;10(13):e019904. doi: 10.1161/JAHA.120.019904. Epub 2021 Jun 22. 2021
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| 2 | ROR1, ROR2
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| ROR1 and ROR2-novel targets for neuroblastoma
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| Dave H, Butcher D, Anver M, Bollard CM.
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| Pediatr Hematol Oncol. Sep;36(6):352-364. doi: 10.1080/08880018.2019.1646365. Epub 2019 Aug 23. 2019
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| 3 | ROR1, ROR2
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| ROR1 and ROR2 play distinct and opposing roles in endometrial cancer.
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| Henry CE, Llamosas E, Daniels B, Coopes A, Tang K, Ford CE.
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| Gynecol Oncol. Mar;148(3):576-584. doi: 10.1016/j.ygyno.2018.01.025. Epub 2018 Feb 1. 2018
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| 4 | IFT20, ROR2
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| Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness.
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| Nishita M, Park SY, Nishio T, Kamizaki K, Wang Z, Tamada K, Takumi T, Hashimoto R, Otani H, Pazour GJ, Hsu VW, Minami Y.
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| Sci Rep 7(1):1. doi: 10.1038/s41598-016-0028-x.
2017
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| 5 | ROR1, ROR2
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| Silencing ROR1 and ROR2 inhibits invasion and adhesion in an organotypic model of ovarian cancer metastasis.
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| Henry C, Hacker N, Ford C.
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| Oncotarget Nov 20;8(68):112727-112738. doi: 10.18632/oncotarget.22559. 2017
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| 6 | DVL1, DVL3, RBNS3, RBNSOS, ROR2
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| DVL3 Alleles Resulting in a -1 Frameshift of the Last Exon Mediate Autosomal-Dominant Robinow Syndrome.
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| White JJ, Mazzeu JF, Hoischen A, Bayram Y, Withers M, Gezdirici A, Kimonis V, Steehouwer M, Jhangiani SN, Muzny DM, Gibbs RA; Baylor-Hopkins Center for Mendelian Genomics, van Bon BW, Sutton VR, Lupski JR, Brunner HG, Carvalho CM.
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| Am J Hum Genet 98(3):553-61. doi: 10.1016/j.ajhg.2016.01.005. Epub 2016 Feb 25.
2016
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| 7 | GDF6, ROR2
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| Ror2 signaling is required for local upregulation of GFD6 and activation of BMP signaling at the neural plate border.
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| Schille C, Bayerlová M, Bleckmann A, Schambony A.
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| Development 143(17):3182-94. doi: 10.1242/dev.135426.
2016
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| 8 | ANPEP, ROR2
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| CD13 and ROR2 Permit Isolation of Highly Enriched Cardiac Mesoderm from Differentiating Human Embryonic Stem Cells.
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| Skelton RJ, Brady B, Khoja S, Sahoo D, Engel J, Arasaratnam D, Saleh KK, Abilez OJ, Zhao P, Stanley EG, Elefanty AG, Kwon M, Elliott DA, Ardehali R.
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| Stem Cell Reports 6(1):95-108. doi: 10.1016/j.stemcr.2015.11.006.
2016
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| 9 | CHST11, LITAF, ROR2, RREB1, SPATA5, TWIST1
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| Genome-wide Twist1 occupancy in endocardial cushion cells, embryonic limb buds, and peripheral nerve sheath tumor cells.
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| Lee MP, Ratner N, Yutzey KE.
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| BMC Genomics 15:821. doi: 10.1186/1471-2164-15-821.
2014
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| 10 | ROR2, WNT5A
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| Wnt5a signaling is a substantial constituent in bone morphogenetic protein-2-mediated osteoblastogenesis.
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| Nemoto E, Ebe Y, Kanaya S, Tsuchiya M, Nakamura T, Tamura M, Shimauchi H.
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| Biochem Biophys Res Commun 422(4):627-32. doi: 10.1016/j.bbrc.2012.05.039. Epub 2012 May 15.
2012
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| 11 | MMP13, ROR2, WNT5A
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| Dissection of Wnt5a-Ror2 signaling leading to matrix metalloproteinase (MMP-13) expression.
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| Yamagata K, Li X, Ikegaki S, Oneyama C, Okada M, Nishita M, Minami Y.
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| J Biol Chem 287(2):1588-99. doi: 10.1074/jbc.M111.315127. Epub 2011 Nov 28.
2012
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| 12 | ROR2, WNT5A
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| Critical role of Wnt5a-Ror2 signaling in motility and invasiveness of carcinoma cells following Snail-mediated epithelial-mesenchymal transition.
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| Ren D, Minami Y, Nishita M.
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| Genes Cells 16(3):304-15. doi: 10.1111/j.1365-2443.2011.01487.x.
2011
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| 13 | ROR2, WNT5A
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| Wnt5a regulates growth, patterning, and odontoblast differentiation of developing mouse tooth.
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| Lin M, Li L, Liu C, Liu H, He F, Yan F, Zhang Y, Chen Y.
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| Dev Dyn 240(2):432-40. doi: 10.1002/dvdy.22550.
2011
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| 14 | BDB1, RBNS2, ROR2, VANGL2, WNT5A
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| Disruption of PCP signaling causes limb morphogenesis and skeletal defects and may underlie Robinow syndrome and brachydactyly type B.
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| Wang B, Sinha T, Jiao K, Serra R, Wang J.
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| Hum Mol Genet 20(2):271-85. Epub 2010 Oct 20.
2011
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| 15 | KITLG, ROR2, WNT5A
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| Ror2 enhances polarity and directional migration of primordial germ cells.
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| Laird DJ, Altshuler-Keylin S, Kissner MD, Zhou X, Anderson KV.
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| PLoS Genet 7(12):e1002428. doi: 10.1371/journal.pgen.1002428. Epub 2011 Dec 22.
2011
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| 16 | ROR2
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| Identification of Ror2 as a hypoxia-inducible factor target in von Hippel-Lindau-associated renal cell carcinoma.
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| Wright TM, Rathmell WK.
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| J Biol Chem 285(17):12916-24. Epub 2010 Feb 25.
2010
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| 17 | FZD7, ROR2
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| Ror2/Frizzled complex mediates Wnt5a-induced AP-1 activation by regulating Dishevelled polymerization.
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| Nishita M, Itsukushima S, Nomachi A, Endo M, Wang Z, Inaba D, Qiao S, Takada S, Kikuchi A, Minami Y.
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| Mol Cell Biol 30(14):3610-9. Epub 2010 May 10. 2010
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| 18 | ROR1, ROR2
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| Ror1-Ror2 complexes modulate synapse formation in hippocampal neurons.
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| Paganoni S, Bernstein J, Ferreira A.
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| Neuroscience 165(4):1261-74. Epub 2009 Dec 1.
2010
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| 19 | ROR1, ROR2
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| Ror-family receptor tyrosine kinases in noncanonical Wnt signaling: their implications in developmental morphogenesis and human diseases.
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| Minami Y, Oishi I, Endo M, Nishita M.
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| Dev Dyn 239(1):1-15. Review.
2010
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| 20 | ROR1, ROR2
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| Mice lacking the orphan receptor ror1 have distinct skeletal abnormalities and are growth retarded.
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| Lyashenko N, Weissenböck M, Sharir A, Erben RG, Minami Y, Hartmann C.
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| Dev Dyn 239(8):2266-77.
2010
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| 21 | ROR2
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| Receptor tyrosine kinase-like orphan receptor 2 (ROR2) and Indian hedgehog regulate digit outgrowth mediated by the phalanx-forming region.
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| Witte F, Chan D, Economides AN, Mundlos S, Stricker S.
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| Proc Natl Acad Sci U S A 107(32):14211-6. Epub 2010 Jul 26.
2010
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| 22 | ROR2
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| Biochemical and functional characterization of the Ror2/BRIb receptor complex.
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| Sammar M, Sieber C, Knaus P.
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| Biochem Biophys Res Commun. 27;381(1):1-6 2009
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| 23 | BDB1, ROR2
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| A novel single-base deletion in ROR2 causes atypical brachydactyly type B1 with cutaneous syndactyly in a large Chinese family.
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| Lv D, Luo Y, Yang W, Cao L, Wen Y, Zhao X, Sun M, Lo WH, Zhang X.
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| J Hum Genet 54(7):422-5. Epub 2009 May 22.
2009
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| 24 | BDB1, RBNS, ROR2
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| A gradient of ROR2 protein stability and membrane localization confers brachydactyly type B or Robinow syndrome phenotypes.
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| Schwarzer W, Witte F, Rajab A, Mundlos S, Stricker S.
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| Hum Mol Genet 18(21):4013-21. Epub 2009 Jul 29.PMID: 19640924 2009
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| 25 | ROR2, WTIP
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| The LIM domain protein Wtip interacts with the receptor tyrosine kinase Ror2 and inhibits canonical Wnt signalling.
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| van Wijk NV, Witte F, Feike AC, Schambony A, Birchmeier W, Mundlos S, Stricker S.
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| Biochem Biophys Res Commun 390(2):211-6. Epub 2009 Sep 26.PMID: 19785987 2009
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| 26 | RBNS, ROR2
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| Robinow syndrome: phenotypic variability in a family with a novel intragenic ROR2 mutation.
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| Brunetti-Pierri N, Del Gaudio D, Peters H, Justino H, Ott CE, Mundlos S, Bacino CA.
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| Am J Med Genet A 146A(21):2804-9.
2008
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| 27 | BDB1, RBNS, ROR2
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| The mutation ROR2W749X, linked to human BDB, is a recessive mutation in the mouse, causing brachydactyly, mediating patterning of joints and modeling recessive Robinow syndrome.
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| Raz R, Stricker S, Gazzerro E, Clor JL, Witte F, Nistala H, Zabski S, Pereira RC, Stadmeyer L, Wang X, Gowen L, Sleeman MW, Yancopoulos GD, Canalis E, Mundlos S, Valenzuela DM, Economides AN.
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| Development 135(9):1713-23. Epub 2008 Mar 19.PMID: 18353862 2008
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| 28 | FZD2, ROR2
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| Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2.
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| Li C, Chen H, Hu L, Xing Y, Sasaki T, Villosis MF, Li J, Nishita M, Minami Y, Minoo P.
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| BMC Mol Biol 9:11. doi: 10.1186/1471-2199-9-11.
2008
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| 29 | DEL9Q22, NBCCS2, PTCH1, ROR2
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| A girl with deletion 9q22.1-q22.32 including the PTCH and ROR2 genes identified by genome-wide array-CGH.
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| Nowakowska B, Kutkowska-Kazmierczak A, Stankiewicz P, Bocian E, Obersztyn E, Ou Z, Cheung SW, Cai WW.
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| Am J Med Genet A 143(16):1885-9. 2007
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| 30 | ROR2, RBNS
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| Novel Robinow syndrome causing mutations in the proximal region of the frizzled-like domain of ROR2 are retained in the endoplasmic reticulum.
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| Ali BR, Jeffery S, Patel N, Tinworth LE, Meguid N, Patton MA, Afzal AR.
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| Hum Genet 122(3-4):389-95. Epub 2007 Jul 31. 2007
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| 31 | DEL9Q22, NBCCS2, PTCH1, ROR2
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| Perinatal findings and molecular cytogenetic analyses of de novo interstitial deletion of 9q (9q22.3-->q31.3) associated with Gorlin syndrome.
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| Chen CP, Lin SP, Wang TH, Chen YJ, Chen M, Wang W.
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| Prenat Diagn 26(8):725-9. 2006
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| 32 | BDB1, ROR2
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| Brachydactyly type B1: report of a family with de novo ROR2 mutation.
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| Hamamy H, Saleh N, Oldridge M, Al-Hadidy A, Ajlouni K.
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| Clin Genet 70(6):538-40. No abstract available. 2006
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| 33 | DEL9Q22, NBCCS2, PTCH1, ROR2
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| Delineation of an interstitial 9q22 deletion in basal cell nevus syndrome.
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| Boonen SE, Stahl D, Kreiborg S, Rosenberg T, Kalscheuer V, Larsen LA, Tommerup N, Brondum-Nielsen K, Tumer Z.
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| Am J Med Genet A 132(3):324-8. 2005
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| 34 | RBNS,ROR2
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| ER-associated protein degradation is a common mechanism underpinning numerous monogenic diseases including Robinow syndrome.
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| Chen Y, Bellamy WP, Seabra MC, Field MC, Ali BR.
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| Hum Mol Genet 14(17):2559-69. Epub 2005 Jul 27. 2005
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| 35 | ROR1, ROR2
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| Comparative genomics on ROR1 and ROR2 orthologs.
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| Katoh M, Katoh M.
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| Oncol Rep 14(5):1381-4.
2005
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| 36 | DEL9Q22, PTCH1, ROR2, NPS1
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| Interstitial deletion 9q22.32-q33.2 associated with additional familial translocation t(9;17)(q34.11;p11.2) in a patient with Gorlin-Goltz syndrome and features of Nail-Patella syndrome.
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| Midro AT, Panasiuk B, Tumer Z, Stankiewicz P, Silahtaroglu A, Lupski JR, Zemanova Z, Stasiewicz-Jarocka B, Hubert E, Tarasow E, Famulski W, Zadrozna-Tolwinska B, Wasilewska E, Kirchhoff M, Kalscheuer V, Michalova K, Tommerup N.
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| Am J Med Genet A 124(2):179-91. Review. 2004
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| 37 | ROR2
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| Ror2 knockout mouse as a model for the developmental pathology of autosomal recessive Robinow syndrome
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| Schwabe, G. C.; Trepczik, B.; Suring, K.; Brieske, N.; Tucker, A. S.; Sharpe, P. T.; Minami, Y.; Mundlos, S.
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| Dev. Dyn. 229: 400-410 2004
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| 38 | ROR1, ROR2
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| Expression and subcellular localization of Ror tyrosine kinase receptors are developmentally regulated in cultured hippocampal neurons.
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| Paganoni S, Ferreira A.
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| J Neurosci Res 73(4):429-40. 2003
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| 39 | DEL9Q22, NBCCS2, PTCH1, ROR2
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| Interstitial deletion of chromosome 9, int del(9)(9q22.31-q31.2), including the genes causing multiple basal cell nevus syndrome and Robinow/brachydactyly 1 syndrome.
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| Olivieri C, Maraschio P, Caselli D, Martini C, Beluffi G, Maserati E, Danesino C.
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| Eur J Pediatr 162(2):100-3. Epub 2002 Dec 10. 2003
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| 40 | BDB1,RBNS,ROR2
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| One gene, two phenotypes: ROR2 mutations in autosomal recessive Robinow syndrome and autosomal dominant brachydactyly type B.
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| Afzal AR, Jeffery S.
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| Hum Mutat 22(1):1-11. 2003
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| 41 | FZD2, ROR2
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| The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway.
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| Oishi I, Suzuki H, Onishi N, Takada R, Kani S, Ohkawara B, Koshida I, Suzuki K, Yamada G, Schwabe GC, Mundlos S, Shibuya H, Takada S, Minami Y.
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| Genes Cells 8(7):645-54.
2003
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| 42 | RBNS,ROR1,ROR2
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| Robinow syndrome.
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| Patton MA, Afzal AR.
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| J Med Genet 39(5):305-10. Review. 2002
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| 43 | ECM2, FGD3, HSAN1, NINJ1, OGN, OMD, ROR2, SPTLC1
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| SPTLC1 is mutated in hereditary sensory neuropathy, type 1.
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| Bejaoui K, Wu C, Scheffler MD, Haan G, Ashby P, Wu L, de Jong P, Brown RH Jr.
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| Nat Genet 27(3):261-2. 2001
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| 44 | ROR2
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| Loss of mRor1 enhances the heart and skeletal abnormalities in mRor2-deficient mice: redundant and pleiotropic functions of mRor1 and mRor2 receptor tyrosine kinases.
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| Nomi, M.; Oishi, I.; Kani, S.; Suzuki, H.; Matsuda, T.; Yoda, A.; Kitamura, M.; Itoh, K.; Takeuchi, S.; Takeda, K.; Akira, S.; Ikeya, M.; Takada, S.; Minami, Y.
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| Molec. Cell. Biol. 21: 8329-8335 2001
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| 45 | BDB1, ROR2
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| Dominant mutations in ROR2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B.
|
| Oldridge M, M Fortuna A, Maringa M, Propping P, Mansour S, Pollitt C, DeChiara TM, Kimble RB, Valenzuela DM, Yancopoulos GD, Wilkie AO.
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| Nat Genet 24(3):275-8. No abstract available. 2000
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| 46 | ROR2
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| Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development.
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| DeChiara TM, Kimble RB, Poueymirou WT, Rojas J, Masiakowski P, Valenzuela DM, Yancopoulos GD.
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| Nat Genet 24(3):271-4. No abstract available. 2000
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| 47 | RBNS,ROR2
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| Linkage of recessive Robinow syndrome to a 4 cM interval on chromosome 9q22.
|
| Afzal AR, Rajab A, Fenske C, Crosby A, Lahiri N, Ternes-Pereira E, Murday VA, Houlston R, Patton MA, Jeffery S.
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| Hum Genet 106(3):351-4. 2000
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| 48 | BDB1, ROR2
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| Distinct mutations in the receptor tyrosine kinase gene ROR2 cause brachydactyly type B.
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| Schwabe GC, Tinschert S, Buschow C, Meinecke P, Wolff G, Gillessen-Kaesbach G, Oldridge M, Wilkie AO, Komec R, Mundlos S.
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| Am J Hum Genet 67(4):822-31. 2000
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| 49 | RBNS,ROR2
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| Recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by mutation of ROR2.
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| Afzal AR, Rajab A, Fenske CD, Oldridge M, Elanko N, Ternes-Pereira E, Tuysuz B, Murday VA, Patton MA, Wilkie AO, Jeffery S.
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| Nat Genet 25(4):419-22. 2000
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| 50 | ROR2
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| Mutation of the gene encoding the ROR2 tyrosine kinase causes autosomal recessive Robinow syndrome.
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| van Bokhoven H, Celli J, Kayserili H, van Beusekom E, Balci S, Brussel W, Skovby F, Kerr B, Percin EF, Akarsu N, Brunner HG.
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| Nat Genet 25(4):423-6. 2000
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| 51 | ROR2
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| Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation.
|
| Takeuchi, S.; Takeda, K.; Oishi, I.; Nomi, M.; Ikeya, M.; Itoh, K.; Tamura, S.; Ueda, T.; Hatta, T.; Otani, H.; Terashima, T.; Takada, S.; Yamamura, H.; Akira, S.; Minami, Y.
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| Genes Cells 5: 71-78 2000
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| 52 | ROR2
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| A physical map of 30,000 human genes.
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| Deloukas, P.; Schuler, G. D.; Gyapay, G.; Beasley, E. M.; Soderlund, C.; Rodriguez-Tome, P.; Hui, L.; Matise, T. C.; McKusick, K. B.; Beckmann, J. S.; Bentolila, S.; Bihoreau, M.-T.; and 53 others
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| Science 282: 744-746 1998
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| 53 | ROR2
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| A novel family of cell surface receptors with tyrosine kinase-like domain.
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| Masiakowski P, Carroll RD.
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| J Biol Chem 267(36):26181-90. 1992
|