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FLASH GENE
Symbol SLC39A1 contributors: mct/npt - updated : 24-03-2010
HGNC name solute carrier family 39 (zinc transporter), member 1
HGNC id 12876
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • eight transmembrane segments
  • nine possible N myristylation sites
  • a potential protein kinase
  • C phosphorylation site
  • four potential protein kinase II phosphorylation sites
    • HOMOLOGY
    Homologene
    FAMILY
  • ZIP transporter family
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text integral membrane protein
    basic FUNCTION
  • di, tri-valent inorganic cation transporter
  • major zinc uptake transporter for the accumulation of zinc in prostate cells
  • playing a role in osteoclast activity
  • important zinc uptake transporter involved in the unique ability of prostate cells to accumulate high cellular zinc levels (Desouki 2007)
  • important for the extraction of zinc from circulation as the primary source of cellular zinc (Desouki 2007)
  • have unique cell-specific functions during adaptation to zinc deficiency (Kambe 2009)
  • involved in the initiation of synaptonemal complex formation, is also important for nonexchange chromosomes segregation (Newnham 2010)
  • promotes tethering of nonexchange chromosomes at their centromeres throughout meiotic prophase, and this tethering correlates with improved segregation at the first meiotic division (Newnham 2010)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in prostate adenocarcinoma (Desouki 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS