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FLASH GENE
Symbol LARS2 contributors: mct - updated : 25-05-2013
HGNC name leucyl-tRNA synthetase 2, mitochondrial
HGNC id 17095
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • mitochondrial signal sequence (encompassing first 21 aa)
    • mono polymer monomer
    HOMOLOGY
    interspecies homolog to rattus Lars2 (87 pc)
    homolog to murine Lars2 (86.6 pc)
    Homologene
    FAMILY
  • class-I aminoacyl-tRNA synthetase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    text
  • localizes exclusively to mitochondria
    • basic FUNCTION
  • acting as a ligase
  • catalyzing the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid
  • its activity is required in the cytoplasm and in mitochondria for the translation of nuclearly and mitochondrially encoded genes, respectively
    • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PRLTS4
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    by both genetic and epigenetic mechanisms may be a common and important event in the carcinogenesis of nasopharyngeal carcinoma
    Susceptibility to type 2 diabetes
    Variant & Polymorphism SNP
  • 3243A>G mutation may have a pathophysiologic role in bipolar disorder and schizophrenia
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS