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FLASH GENE
Symbol LARS2 contributors: mct - updated : 25-05-2013
HGNC name leucyl-tRNA synthetase 2, mitochondrial
HGNC id 17095
Corresponding disease
PRLTS4 Perrault Syndrome 4
Location 3p21.31      Physical location : 45.430.074 - 45.590.328
Synonym name
  • precursor of mitochondrial leucyl tRNA synthetase
  • leucine tRNA ligase 2, mitocondrial
  • leucine translase
  • Synonym symbol(s) KIAA0028, LEURS, MGC26121
    EC.number 6.1.1.4
    DNA
    TYPE functioning gene
    STRUCTURE 160.25 kb     22 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 4203 101.8 903 - 2000 10684970
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunetonsils   moderately
    Reproductivemale systemtestis  moderately
    Respiratoryrespiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text highly in umbilical cord
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • mitochondrial signal sequence (encompassing first 21 aa)
  • mono polymer monomer
    HOMOLOGY
    interspecies homolog to rattus Lars2 (87 pc)
    homolog to murine Lars2 (86.6 pc)
    Homologene
    FAMILY
  • class-I aminoacyl-tRNA synthetase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    text
  • localizes exclusively to mitochondria
  • basic FUNCTION
  • acting as a ligase
  • catalyzing the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid
  • its activity is required in the cytoplasm and in mitochondria for the translation of nuclearly and mitochondrially encoded genes, respectively
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PRLTS4
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    by both genetic and epigenetic mechanisms may be a common and important event in the carcinogenesis of nasopharyngeal carcinoma
    Susceptibility to type 2 diabetes
    Variant & Polymorphism SNP
  • 3243A>G mutation may have a pathophysiologic role in bipolar disorder and schizophrenia
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS