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FLASH GENE
Symbol LIMD1 contributors: mct/npt/pgu - updated : 04-01-2010
HGNC name LIM domains containing 1
HGNC id 6612
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cells
SystemCellPubmedSpeciesStageRna symbol
Respiratoryalveolar cell type 2
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three coiled-coil LIM domains (cysteine rich consensus sequence with two distinct zinc binding subdomains) at the C terminus
  • a proline and serine rich region
  • a leucine-rich nuclear export signal facilitating cytosolic/nuclear shuttling
    • HOMOLOGY
    interspecies ortholog to murine Limd1
    ortholog to Drosophila Cg11063
    Homologene
    FAMILY
  • Ajuba LIM proteins family
  • zyxin/ajuba family
    • CATEGORY adaptor , transcription factor , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • predominantly in the cytoplasm
  • localizes to E-cadherin cell&
    • 65533;cell adhesive junctions, yet also translocates to the nucleus where it has been shown to function as an RB corepressor
    basic FUNCTION
  • inhibiting E2F-mediated transcription, and suppressing the expression of the majority of genes with E2F1-responsive elements
  • tumor-suppressor gene involved in human lung cancer development
  • has the potential to communicate cell extrinsic or environmental cues with nuclear responses (Sharp 2008)
  • implicated in the regulation of stress osteoclastogenesis through an interaction with the p62/sequestosome protein
  • novel regulator of both bone osetoclast and bone osteoblast development and function
  • potentially important regulator of osteoclast development under conditions of stress
  • directly interacts with RB1 and is thought to play a role in suppressing tumor growth
  • adaptor protein that exhibit the potential to communicate cell adhesive events with nuclear responses to remodel epithelia
  • having role as negative regulatorof the Hippo signaling pathway
  • required for microRNA-mediated gene silencing
  • involvement of LIMD1 in miRNA-mediated silencing is consistent with its tumor suppressive role
    • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text cell growth and maintenance
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+ (2 ions linked LIM domain)
    • protein
  • interacts with TRAF6, a critical cytosolic regulator of RANK-L-regulated osteoclast development
  • interacts with the retinoblastoma protein (RB), inhibits E2F-mediated transcription, and suppresses expression of the majority of genes with E2F1-responsive elements
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in lung cancer, by CpG methylation
    constitutional     --over  
    during osteoclast differentiation
    tumoral     --low  
    in lung and breast cancers (absence/loss of nuclear staining showed a strong correlation with patient survival and was indicative of poor prognosis)
    Susceptibility to breast cancer
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS