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FLASH GENE

Symbol

LIMD1

contributors: mct/npt/pgu - updated : 04-01-2010

HGNC name	LIM domains containing 1
HGNC id	6612

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	86.43 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	Binding site
text structure	LIMD1 promoter contains a conserved binding motif for the transcription factor SPI1

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014240 8 - 6284 NP_055055 - 676 - 2008 19060205

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

cells

System Cell Pubmed Species Stage Rna symbol Respiratory alveolar cell type 2

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	three coiled-coil LIM domains (cysteine rich consensus sequence with two distinct zinc binding subdomains) at the C terminus
	a proline and serine rich region
	a leucine-rich nuclear export signal facilitating cytosolic/nuclear shuttling

HOMOLOGY

interspecies	ortholog to murine Limd1
	ortholog to Drosophila Cg11063

Homologene

FAMILY	Ajuba LIM proteins family
	zyxin/ajuba family

CATEGORY

adaptor , transcription factor , signaling

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus
text	predominantly in the cytoplasm
	localizes to E-cadherin cell&
	65533;cell adhesive junctions, yet also translocates to the nucleus where it has been shown to function as an RB corepressor

basic FUNCTION	inhibiting E2F-mediated transcription, and suppressing the expression of the majority of genes with E2F1-responsive elements
	tumor-suppressor gene involved in human lung cancer development
	has the potential to communicate cell extrinsic or environmental cues with nuclear responses (Sharp 2008)
	implicated in the regulation of stress osteoclastogenesis through an interaction with the p62/sequestosome protein
	novel regulator of both bone osetoclast and bone osteoblast development and function
	potentially important regulator of osteoclast development under conditions of stress
	directly interacts with RB1 and is thought to play a role in suppressing tumor growth
	adaptor protein that exhibit the potential to communicate cell adhesive events with nuclear responses to remodel epithelia
	having role as negative regulatorof the Hippo signaling pathway
	required for microRNA-mediated gene silencing
	involvement of LIMD1 in miRNA-mediated silencing is consistent with its tumor suppressive role

CELLULAR PROCESS	cell life, differentiation
	nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

development

text	cell growth and maintenance

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+ (2 ions linked LIM domain)

protein	interacts with TRAF6, a critical cytosolic regulator of RANK-L-regulated osteoclast development
	interacts with the retinoblastoma protein (RB), inhibits E2F-mediated transcription, and suppresses expression of the majority of genes with E2F1-responsive elements

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in lung cancer, by CpG methylation constitutional     --over   during osteoclast differentiation tumoral     --low   in lung and breast cancers (absence/loss of nuclear staining showed a strong correlation with patient survival and was indicative of poor prognosis)

Susceptibility

to breast cancer

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS