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FLASH GENE

Symbol

SIRT2

contributors: mct - updated : 17-10-2019

HGNC name	sirtuin 2
HGNC id	10886

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   down-regulated in gliomas and glioma cell lines, which are characterized by aneuploidy constitutional     --low   in both preeclampsia (PE) and fetal growth restriction (FGR) constitutional     --low   of SIRT2 protein expression in both Preeclampsia (PE) and fetal growth restriction (FGR) placentas

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurology neurodegenerative huntington chorea SIRT2 inhibition is a promising avenue for HD therapy neuromuscular myopathy congenital SIRT2 inhibitors and AMPK inhibitors as potential therapeutics for OPMD and perhaps other muscular dystrophies and polyAla diseases cancer     utilization of sirtuin activators that specifically target SIRT2 could serve as potential anticancer therapy miscelleaneous     SIRT2 targeting may be therapeutically beneficial in diseases where aggregation of misfolded proteins is central to disease pathogenesis neurology neurodegenerative   viable molecular target for neuroprotective therapy. neurology neurodegenerative   therapeutic target in the most prevalent neurodegenerative diseases that undergo with axonal degeneration associated with redox and energetic dyshomeostasis cardiovascular aquired   potential target for therapeutic interventions in aging- and stress-induced cardiac hypertrophy cancer hemopathy   SIRT2 serves as a promising target for further therapeutic investigations neurology neurodegenerative Parkinson/dementia Parkinsonism inhibition of Sirtuin 2 expression may be a neuroprotective measure in Parkinson's disease

ANIMAL & CELL MODELS