| 1 | BARD1, BRCA1, SIRT2
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| SIRT2 promotes BRCA1-BARD1 heterodimerization through deacetylation.
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| Minten EV, Kapoor-Vazirani P, Li C, Zhang H, Balakrishnan K, Yu DS.
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| Cell Rep. Mar 30;34(13):108921. doi: 10.1016/j.celrep.2021.108921. 2021
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| 2 | GORASP2, SIRT2
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| SIRT2 deacetylates GRASP55 to facilitate post-mitotic Golgi assembly.
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| Zhang X, Brachner A, Kukolj E, Slade D, Wang Y.
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| J Cell Sci Cell Sci. 2019 Oct 11. pii: jcs.232389. doi: 10.1242/jcs.232389. [Epub ahead of print]
2019
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| 3 | SIRT2
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| SIRT2: Controversy and multiple roles in disease and physiology.
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| Wang Y, Yang J, Hong T, Chen X, Cui L.
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| Ageing Res Rev 55:100961. doi: 10.1016/j.arr.2019.100961. Epub 2019 Sep 7. Review.
2019
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| 4 | SIRT2
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| Downregulation of SIRT2 by Chronic Stress Reduces Expression of Synaptic Plasticity-related Genes through the Upregulation of Ehmt2.
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| Wang SE, Ko SY, Jo S, Jo HR, Han J, Kim YS, Son H.
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| Exp Neurobiol 28(4):537-546. doi: 10.5607/en.2019.28.4.537.
2019
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| 5 | SIRT2
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| Sirt2 Regulates Radiation-Induced Injury.
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| Nguyen P, Shukla S, Liu R, Abbineni G, Smart DK.
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| Radiat Res 191(5):398-412. doi: 10.1667/RR15282.1. Epub 2019 Mar 5.
2019
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| 6 | AK7, SIRT2
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| The SIRT2 inhibitor AK-7 decreases cochlear cell apoptosis and attenuates noise-induced hearing loss
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| Liu Y, Ao L, Li Y, Zhao Y, Wen Y, Ding H.
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| Biochem Biophys Res Commun. Feb 12;509(3):641-646. doi: 10.1016/j.bbrc.2018.12.084. Epub 2019 Jan 4. Erratum in: Biochem Biophys Res Commun. 2019 Mar 26;51 2019
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| 7 | NQO1, SIRT2
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| NQO1 regulates mitotic progression and response to mitotic stress through modulating SIRT2 activity.
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| Kang HJ, Song HY, Ahmed MA, Guo Y, Zhang M, Chen C, Cristofanilli M, Horiuchi D, Vassilopoulos A.
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| Free Radic Biol Med 126:358-371. doi: 10.1016/j.freeradbiomed.2018.08.009. Epub 2018 Aug 13.
2018
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| 8 | SIRT2
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| SIRT2 reduces actin polymerization and cell migration through deacetylation and degradation of HSP90.
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| Min JS, Kim JC, Kim JA, Kang I, Ahn JK.
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| Biochim Biophys Acta Mol Cell Res 1865(9):1230-1238. doi: 10.1016/j.bbamcr.2018.06.005. Epub 2018 Jun 14.
2018
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| 9 | GCKR, SIRT2
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| Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein.
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| Watanabe H, Inaba Y, Kimura K, Matsumoto M, Kaneko S, Kasuga M, Inoue H.
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| Nat Commun 9(1):30. doi: 10.1038/s41467-017-02537-6.
2018
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| 10 | RIPK1, SIRT2
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| Key players of the necroptosis pathway RIPK1 and SIRT2 are altered in placenta from preeclampsia and fetal growth restriction.
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| Hannan NJ, Beard S, Binder NK, Onda K, Kaitu'u-Lino TJ, Chen Q, Tuohey L, De Silva M, Tong S.
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| Placenta 51:1-9. doi: 10.1016/j.placenta.2017.01.002. Epub 2017 Jan 4.
2017
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| 11 | SIRT2, SPOP
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| SPOP promotes SIRT2 degradation and suppresses non-small cell lung cancer cell growth.
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| Luo J, Bao YC, Ji XX, Chen B, Deng QF, Zhou SW.
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| Biochem Biophys Res Commun 483(2):880-884. doi: 10.1016/j.bbrc.2017.01.027. Epub 2017 Jan 7.
2017
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| 12 | SIRT2
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| Loss of SIRT2 leads to axonal degeneration and locomotor disability associated with redox and energy imbalance.
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| Fourcade S, Morató L, Parameswaran J, Ruiz M, Ruiz-Cortés T, Jové M, Naudí A, Martínez-Redondo P, Dierssen M, Ferrer I, Villarroya F, Pamplona R, Vaquero A, Portero-Otín M, Pujol A.
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| Aging Cell 16(6):1404-1413. doi: 10.1111/acel.12682. Epub 2017 Oct 5.
2017
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| 13 | SIRT2, STK11
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| SIRT2 Acts as a Cardioprotective Deacetylase in Pathological Cardiac Hypertrophy.
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| Tang X, Chen XF, Wang NY, Wang XM, Liang ST, Zheng W, Lu YB, Zhao X, Hao DL, Zhang ZQ, Zou MH, Liu DP, Chen HZ.
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| Circulation 136(21):2051-2067. doi: 10.1161/CIRCULATIONAHA.117.028728. Epub 2017 Sep 25.
2017
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| 14 | RIPK1, SIRT2
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| Key players of the necroptosis pathway RIPK1 and SIRT2 are altered in placenta from preeclampsia and fetal growth restriction.
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| Hannan NJ, Beard S, Binder NK, Onda K, Kaitu'u-Lino TJ, Chen Q, Tuohey L, De Silva M, Tong S.
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| Placenta 51:1-9. doi: 10.1016/j.placenta.2017.01.002. Epub 2017 Jan 4.
2017
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| 15 | NFE2L2, SIRT2
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| Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2.
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| Yang X, Park SH, Chang HC, Shapiro JS, Vassilopoulos A, Sawicki KT, Chen C, Shang M, Burridge PW, Epting CL, Wilsbacher LD, Jenkitkasemwong S, Knutson M, Gius D, Ardehali H.
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| J Clin Invest 127(4):1505-1516. doi: 10.1172/JCI88574. Epub 2017 Mar 13.
2017
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| 16 | AK7, SIRT2
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| Sirtuin 2 enhances dopaminergic differentiation via the AKT/GSK-3β/β-catenin pathway. 2017
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| Szegő ÉM, Gerhardt E, Outeiro TF.
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| Neurobiol Aging. Aug;56:7-16. doi: 10.1016/j.neurobiolaging.2017.04.001. Epub 2017 Apr 10 2017
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| 17 | ANKLE2, SIRT2
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| SIRT2 regulates nuclear envelope reassembly through ANKLE2 deacetylation.
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| Kaufmann T, Kukolj E, Brachner A, Beltzung E, Bruno M, Kostrhon S, Opravil S, Hudecz O, Mechtler K, Warren G, Slade D.
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| J Cell Sci 129(24):4607-4621. Epub 2016 Nov 14.
2016
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| 18 | SIRT1, SIRT2
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| Sirtuins 1 and 2 Are Universal Histone Deacetylases.
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| Hsu WW, Wu B, Liu WR.
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| ACS Chem Biol 11(3):792-9. doi: 10.1021/acschembio.5b00886. Epub 2016 Feb 5.
2016
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| 19 | G6PD, SIRT2
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| SIRT2 activates G6PD to enhance NADPH production and promote leukaemia cell proliferation.
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| Xu SN, Wang TS, Li X, Wang YP.
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| Sci Rep 6:32734. doi: 10.1038/srep32734.
2016
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| 20 | CCNA2, CDK2, PLA2G4A, SIRT2
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| Group IVA Cytosolic Phospholipase A2 Regulates the G2-to-M Transition by Modulating the Activity of Tumor Suppressor SIRT2.
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| Movahedi Naini S, Sheridan AM, Force T, Shah JV, Bonventre JV.
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| Mol Cell Biol 35(21):3768-84. doi: 10.1128/MCB.00184-15. Epub 2015 Aug 24.
2015
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| 21 | SIRT2
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| The histone deacetylase sirtuin 2 is a new player in the regulation of platelet function.
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| Moscardó A, Vallés J, Latorre A, Jover R, Santos MT.
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| J Thromb Haemost 13(7):1335-44. doi: 10.1111/jth.13004. Epub 2015 Jun 11.
2015
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| 22 | ABCD3, ASPSCR1, SIRT2
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| Acetylation of TUG protein promotes the accumulation of GLUT4 glucose transporters in an insulin-responsive intracellular compartment.
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| Belman JP, Bian RR, Habtemichael EN, Li DT, Jurczak MJ, Alcázar-Román A, McNally LJ, Shulman GI, Bogan JS.
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| J Biol Chem. Feb 13;290(7):4447-63. doi: 10.1074/jbc.M114.603977. Epub 2015 Jan 5 2015
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| 23 | SIRT1, SIRT2, TIAM1
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| The sirtuins promote Dishevelled-1 scaffolding of TIAM1, Rac activation and cell migration
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| Saxena M, Dykes SS, Malyarchuk S, Wang AE, Cardelli JA, Pruitt K.
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| Oncogene. Jan 8;34(2):188-98. doi: 10.1038/onc.2013.549. Epub 2013 Dec 23. 2015
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| 24 | CBL, CBLB, SIRT2
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| Cbl regulates the activity of SIRT2.
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| Choi YH, Kim H, Han Y, Jin YH, Lee KY.
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| Biochem Biophys Res Commun 453(3):557-62. doi: 10.1016/j.bbrc.2014.09.125. Epub 2014 Oct 5.
2014
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| 25 | CTNNB1, SIRT2
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| SIRT2 interacts with β-catenin to inhibit Wnt signaling output in response to radiation-induced stress.
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| Nguyen P, Lee S, Lorang-Leins D, Trepel J, Smart DK.
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| Mol Cancer Res 12(9):1244-53. doi: 10.1158/1541-7786.MCR-14-0223-T. Epub 2014 May 27.
2014
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| 26 | AK7, SIRT2
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| Inhibition of Sirtuin 2 exerts neuroprotection in aging rats with increased neonatal iron intake
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| Wang X, Wang M, Yang L, Bai J, Yan Z, Zhang Y, Liu Z
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| Neural Regen Res. Nov 1;9(21):1917-22. doi: 10.4103/1673-5374.145361. 2014
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| 27 | MYC, MYCN, SIRT2
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| The histone deacetylase SIRT2 stabilizes Myc oncoproteins.
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| Liu PY, Xu N, Malyukova A, Scarlett CJ, Sun YT, Zhang XD, Ling D, Su SP, Nelson C, Chang DK, Koach J, Tee AE, Haber M, Norris MD, Toon C, Rooman I, Xue C, Cheung BB, Kumar S, Marshall GM, Biankin AV, Liu T.
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| Cell Death Differ 20(3):503-14. doi: 10.1038/cdd.2012.147. Epub 2012 Nov 23.
2013
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| 28 | FRY, SIRT2
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| Furry promotes acetylation of microtubules in the mitotic spindle by inhibition of SIRT2 tubulin deacetylase.
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| Nagai T, Ikeda M, Chiba S, Kanno S, Mizuno K.
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| J Cell Sci 126(Pt 19):4369-80. doi: 10.1242/jcs.127209. Epub 2013 Jul 25.
2013
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| 29 | RIPK1, SIRT2
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| The NAD-dependent deacetylase SIRT2 is required for programmed necrosis.
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| Narayan N, Lee IH, Borenstein R, Sun J, Wong R, Tong G, Fergusson MM, Liu J, Rovira II, Cheng HL, Wang G, Gucek M, Lombard D, Alt FW, Sack MN, Murphy E, Cao L, Finkel T.
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| Nature 492(7428):199-204. doi: 10.1038/nature11700. Epub 2012 Nov 28. Retraction in: Nature. 2014 Feb 27;506(7489):516.
2012
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| 30 | NKX2-2, SIRT2
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| Sirt2 is a novel in vivo downstream target of Nkx2.2 and enhances oligodendroglial cell differentiation.
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| Ji S, Doucette JR, Nazarali AJ.
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| J Mol Cell Biol 3(6):351-9. doi: 10.1093/jmcb/mjr009. Epub 2011 Jun 13.
2011
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| 31 | SIRT2, SREBF2
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| SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis.
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| Luthi-Carter R, Taylor DM, Pallos J, Lambert E, Amore A, Parker A, Moffitt H, Smith DL, Runne H, Gokce O, Kuhn A, Xiang Z, Maxwell MM, Reeves SA, Bates GP, Neri C, Thompson LM, Marsh JL, Kazantsev AG.
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| Proc Natl Acad Sci U S A 107(17):7927-32. Epub 2010 Apr 8.PMID: 20378838 2010
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| 32 | SIRT1, SIRT2
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| SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2.
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| Peck B, Chen CY, Ho KK, Di Fruscia P, Myatt SS, Coombes RC, Fuchter MJ, Hsiao CD, Lam EW.
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| Mol Cancer Ther 9(4):844-55. Epub 2010 Apr 6.PMID: 20371709 2010
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| 33 | SIRT2
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| SIRT2 downregulation confers resistance to microtubule inhibitors by prolonging chronic mitotic arrest.
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| Inoue T, Nakayama Y, Yamada H, Li YC, Yamaguchi S, Osaki M, Kurimasa A, Hiratsuka M, Katoh M, Oshimura M.
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| Cell Cycle 8(8):1279-91. Epub 2009 Apr 19.PMID: 19282667 2009
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| 34 | SIRT2
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| SIRT2 suppresses adipocyte differentiation by deacetylating FOXO1 and enhancing FOXO1's repressive interaction with PPARgamma.
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| Wang F, Tong Q.
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| Mol Biol Cell 20(3):801-8. Epub 2008 Nov 26.PMID: 19037106 2009
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| 35 | OPMD, PABPN1, SIRT2
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| Sirtuin inhibition protects from the polyalanine muscular dystrophy protein PABPN1.
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| Catoire H, Pasco MY, Abu-Baker A, Holbert S, Tourette C, Brais B, Rouleau GA, Parker JA, Néri C.
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| Hum Mol Genet 17(14):2108-17. Epub 2008 Apr 7.
2008
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| 36 | EP300, SIRT2
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| Acetylation of Sirt2 by p300 attenuates its deacetylase activity.
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| Han Y, Jin YH, Kim YJ, Kang BY, Choi HJ, Kim DW, Yeo CY, Lee KY.
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| Biochem Biophys Res Commun 375(4):576-80. Epub 2008 Aug 21.
2008
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| 37 | CDK1, SIRT2
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| Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation.
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| North BJ, Verdin E.
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| J Biol Chem 282(27):19546-55. Epub 2007 May 8. 2007
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| 38 | SIRT2
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| Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease.
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| Outeiro TF, Kontopoulos E, Altmann SM, Kufareva I, Strathearn KE, Amore AM, Volk CB, Maxwell MM, Rochet JC, McLean PJ, Young AB, Abagyan R, Feany MB, Hyman BT, Kazantsev AG.
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| Science 317(5837):516-9. Epub 2007 Jun 21. 2007
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| 39 | SIRT2
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| SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress.
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| Inoue T, Hiratsuka M, Osaki M, Yamada H, Kishimoto I, Yamaguchi S, Nakano S, Katoh M, Ito H, Oshimura M.
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| Oncogene 26(7):945-57. Epub 2006 Aug 14.
2007
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| 40 | SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6, SIRT7, SIRT8
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| Sirtuins: critical regulators at the crossroads between cancer and aging.
|
| Saunders LR, Verdin E.
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| Oncogene 26(37):5489-504. Review.
2007
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| 41 | FOXO1, SIRT2
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| SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation.
|
| Jing E, Gesta S, Kahn CR.
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| Cell Metab 6(2):105-14.PMID: 17681146 2007
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| 42 | HTATIP1, SIRT2
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| Distinct roles for the essential MYST family HAT Esa1p in transcriptional silencing.
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| Clarke AS, Samal E, Pillus L.
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| Mol Biol Cell 17(4):1744-57. Epub 2006 Jan 25. 2006
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| 43 | SIRT2
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| FISH-mapping and genomic organization of the NAD-dependent histone deacetylase gene, Sirtuin 2 (Sirt2).
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| Voelter-Mahlknecht S, Ho AD, Mahlknecht U.
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| Int J Oncol 27(5):1187-96. 2005
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| 44 | SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6, SIRT7
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| Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration.
|
| Araki T, Sasaki Y, Milbrandt J.
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| Science 305(5686):1010-3. 2004
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| 45 | HOXA10, SIRT2
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| Human histone deacetylase SIRT2 interacts with the homeobox transcription factor HOXA10.
|
| Bae NS, Swanson MJ, Vassilev A, Howard BH.
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| J Biochem (Tokyo) 135(6):695-700. 2004
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| 46 | SIRT2
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| The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase.
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| North BJ, Marshall BL, Borra MT, Denu JM, Verdin E.
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| Mol Cell 11(2):437-44. 2003
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| 47 | SIRT2
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| Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene.
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| Hiratsuka M, Inoue T, Toda T, Kimura N, Shirayoshi Y, Kamitani H, Watanabe T, Ohama E, Tahimic CG, Kurimasa A, Oshimura M.
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| Biochem Biophys Res Commun 309(3):558-66. 2003
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| 48 | SIRT2
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| Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle.
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| Dryden SC, Nahhas FA, Nowak JE, Goustin AS, Tainsky MA.
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| Mol Cell Biol 23(9):3173-85. 2003
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| 49 | SIRT2, SIRT1
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| Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence.
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| Langley E, Pearson M, Faretta M, Bauer UM, Frye RA, Minucci S, Pelicci PG, Kouzarides T.
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| EMBO J 21(10):2383-96. 2002
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| 50 | SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6, SIRT7
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| Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins.
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| Frye RA.
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| Biochem Biophys Res Commun 273(2):793-8. 2000
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| 51 | SIRT2
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| Characterization of a human gene with sequence homology to Saccharomyces cerevisiae SIR2.
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| Afshar G, Murnane JP.
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| Gene 234(1):161-8. 1999
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| 52 | SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6, SIRT7
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| Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity.
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| Frye RA.
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| Biochem Biophys Res Commun 260(1):273-9. 1999
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| 53 | ABCD3, ASPSCR1, SIRT2
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| ASPL-TFE3 Oncoprotein Regulates Cell Cycle Progression and Induces Cellular Senescence by Up-Regulating p21.
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| Ishiguro N, Yoshida H.
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|
|