| basic FUNCTION
| conserved NAD+-dependent deacetylases and ADP-ribosyltransferases involved in the regulation of cell division, apoptosis, DNA damage repair, genomic silencing, and longevity |
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deacetylating the Lys-40 of alpha-tubulin (role in the cell cycle regulation) |
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involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton |
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involved in chromatin structure |
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involved in control of cellular life span |
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involved in mitotic progression in the normal cell cycle |
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mitotic checkpoint protein that functions in the early metaphase to prevent chromosomal instability |
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acts as an important regulator of adipocyte differentiation through modulation of FOXO1 acetylation/phosphorylation and activity and may play a role in controlling adipose tissue mass and function  |
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responds to nutrient deprivation and energy expenditure to maintain energy homeostasis by promoting lipolysis and inhibiting adipocyte differentiation |
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deacetylase for tubulin and histone H4 |
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function of SIRT2 for centrosome maintenance upon exposure to mitotic stress caused by microtubule inhibitors, but also the existence of a centrosome-mediated signaling pathway to sustain the spindle checkpoint |
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by participating in the stress response to genomic insults, sirtuins are thought to protect against cancer, but they are also emerging as direct participants in the growth of some cancers |
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tubulin deacetylase and an important regulator of cell division and myelinogenesis |
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having an unique role in the control of neuronal metabolism |
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in non-neuronal cells, function as a tubulin deacetylase and a key regulator of cell division and differentiation |
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role in regulating microtubule acetylation patterns in neurons, suggesting a novel mechanism by which neuronal function might become impaired in the aging brain |
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NAD-dependent deacetylase that is an important regulator of programmed necrosis and inhibitors of this deacetylase may constitute a novel approach to protect against necrotic injuries, including ischaemic stroke and myocardial infarction |
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regulation of protein acetylation by SIRT2 plays a central role in platelet function |
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SIRT1 and SIRT2 are NAD(+)-dependent histone deacetylases that operate as post-translational regulators for the deacetylation of acetyllysine |
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function of SIRT2 extends beyond the regulation of microtubules to include the regulation of nuclear envelope dynamics |
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cytoplasmic sirtuin that plays a role in various cellular processes, including tumorigenesis, metabolism, and inflammation |
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link between SIRT2 and physiological aging impacting the axonal compartment of the central nervous system, while supporting a major role for SIRT2 in orchestrating its metabolic regulation |
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inhibits cell motility by suppressing actin polymerization |
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SIRT2 plays a critical role in mediating the radiation-induced DNA damage response, thus regulating radiation-induced cell death and survival |
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plays an important role in the response to stress, thereby modulating depression-like behaviors |
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NAD-dependent sirtuin deacetylase that regulates microtubule and chromatin dynamics, gene expression, cell cycle progression as well as nuclear envelope reassembly |
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SIRT2 may also play a role in Golgi structure formation |
