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FLASH GENE
Symbol ONECUT2 contributors: mct - updated : 08-06-2019
HGNC name one cut domain, family member 2
HGNC id 8139
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a polyglutamine tract,a STP box,a polyhistidine tract,
  • a Drosophila cut-like and a peculiar helix-turn-helix (homeo) -DNA binding domain
    • HOMOLOGY
    intraspecies paralog to ONECUT1, ONECUT3
    Homologene
    FAMILY Onecut (OC) family of transcription factors
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • required for liver differnetiation and metabolism
  • participating to the control of organ development from the forgut and midgut endoderm
  • ONECUT2 and ONECUT3 play redundant roles with ONECUT1 in pancreas development
  • ONECUT1, ONECUT2, ONECUT3 are required at early developmental stages for differentiation of the mesencephalic trigeminal nucleus neurons that are in turn necessary for maintenance of the Locus Coeruleus
  • ONECUT1, ONECUT2 redundantly regulate early retinal cell fates during development
  • ONECUT1, ONECUT2 are involved in dose-dependent regulation of retinal horizontal cell fate
    • CELLULAR PROCESS cell cycle, checkpoint
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • direct target gene of TBX21 (TBX21 transactivates ONECUT2 transcription through putative TBX21 half-sites locating -451 to -347 of OC2 promoter region)
  • ONECUT1 and ONECUT2 transcription factors are the missing hemophilia B Leyden regulators that operate through the -5/-6 site
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Oc2-null mice only have defects in horizontal cells (HCs), with a 50% reduction in their numbers