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FLASH GENE

Symbol

ONECUT2

contributors: mct - updated : 08-06-2019

HGNC name	one cut domain, family member 2
HGNC id	8139

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	18q21.31      Physical location : 55.102.916 - 55.158.529
Synonym symbol(s)	OC-2, OC2

DNA

TYPE	functioning gene
STRUCTURE	55.61 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004852 2 - 16142 NP_004843 - 504 - 2008 18418398

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       predominantly Homo sapiens Fetal Endocrine pancreas         Homo sapiens Fetal Nervous spinal cord anterior horn       Homo sapiens Fetal Urinary kidney         Homo sapiens Visual eye retina       Mus musculus Fetal

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central       Homo sapiens Fetal Nervous peripherous       Homo sapiens Fetal

cells

System Cell Pubmed Species Stage Rna symbol Visual ganglion cell Homo sapiens Visual horizontal association cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a polyglutamine tract,a STP box,a polyhistidine tract,
	a Drosophila cut-like and a peculiar helix-turn-helix (homeo) -DNA binding domain

HOMOLOGY

intraspecies

paralog to ONECUT1, ONECUT3

Homologene

FAMILY

Onecut (OC) family of transcription factors

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	required for liver differnetiation and metabolism
	participating to the control of organ development from the forgut and midgut endoderm
	ONECUT2 and ONECUT3 play redundant roles with ONECUT1 in pancreas development
	ONECUT1, ONECUT2, ONECUT3 are required at early developmental stages for differentiation of the mesencephalic trigeminal nucleus neurons that are in turn necessary for maintenance of the Locus Coeruleus
	ONECUT1, ONECUT2 redundantly regulate early retinal cell fates during development
	ONECUT1, ONECUT2 are involved in dose-dependent regulation of retinal horizontal cell fate

CELLULAR PROCESS	cell cycle, checkpoint
	nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

carbohydrate

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	direct target gene of TBX21 (TBX21 transactivates ONECUT2 transcription through putative TBX21 half-sites locating -451 to -347 of OC2 promoter region)
	ONECUT1 and ONECUT2 transcription factors are the missing hemophilia B Leyden regulators that operate through the -5/-6 site

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Oc2-null mice only have defects in horizontal cells (HCs), with a 50% reduction in their numbers