|
| activated by Moloney murine leukemia proviral insertion in Emu-myc transgenic mouse | |
mice bmi1 show protein transformation of the axial skeleton |
|
mild up-regulation of Bmi1 expression in the adult stem cells of the skeletal muscle leads to a remarkable improvement of muscle function in a mouse model of Duchenne muscular dystrophy  |
|
in Bmi1-null mice, the cerebellar architecture was generally preserved, but the thickness of the granular and molecular layers was markedly reduced |
|
transgenic mice overexpressed bmi show an anterior transformation of axial skeleton |
|
mice Bmi1-/- have a shortened lifespan and develop numerous abnormalities including defects in stem cell self-renewal and thymocyte maturation. Also show a marked elevation in the intracellular levels of ROS |