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Symbol BMI1 contributors: mct/pgu - updated : 06-11-2016
HGNC name BMI1 polycomb ring finger oncogene
HGNC id 1066
  • activated by Moloney murine leukemia proviral insertion in Emu-myc transgenic mouse
  • mice bmi1 show protein transformation of the axial skeleton
  • mild up-regulation of Bmi1 expression in the adult stem cells of the skeletal muscle leads to a remarkable improvement of muscle function in a mouse model of Duchenne muscular dystrophy
  • in Bmi1-null mice, the cerebellar architecture was generally preserved, but the thickness of the granular and molecular layers was markedly reduced
  • transgenic mice overexpressed bmi show an anterior transformation of axial skeleton
  • mice Bmi1-/- have a shortened lifespan and develop numerous abnormalities including defects in stem cell self-renewal and thymocyte maturation. Also show a marked elevation in the intracellular levels of ROS