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FLASH GENE
Symbol RPS6KA6 contributors: mct/npt - updated : 04-02-2009
HGNC name ribosomal protein S6 kinase, 90kDa, polypeptide 6
HGNC id 10435
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two non identical conserved kinase catalytic domains
  • an APE motif
  • a C-terminal docking site for ERK
    • HOMOLOGY
    Homologene
    FAMILY
  • RSK family kinases
  • AGC Ser/Thr protein kinase family
  • S6 kinase subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • ribosomal protein S6 kinase, serine/threonine kinase, non receptor type, involved in neuronal development
  • can participate in non-growth factor signaling as for instance TP53-induced growth arrest (Duemmler 2005)
  • its expression may limit the oncogenic, invasive, and metastatic potential of breast cancer cells (may be, in part, due to its regulation of claudin-2) (Thakur 2008)
    • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • ATP
    • protein
  • RPS6
    • cell & other
    REGULATION
    Other may be regulated by MYC
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast carcinoma
    constitutional   deletion    
    in complex X-linked mental retardation
    tumoral     --low  
    in colon carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS