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FLASH GENE

Symbol

RPS6KA6

contributors: mct/npt - updated : 04-02-2009

HGNC name	ribosomal protein S6 kinase, 90kDa, polypeptide 6
HGNC id	10435

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine parathyroid         Nervous brain       highly Respiratory respiratory tract trachea       Urinary kidney         Visual eye

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two non identical conserved kinase catalytic domains
	an APE motif
	a C-terminal docking site for ERK

HOMOLOGY

Homologene

FAMILY	RSK family kinases
	AGC Ser/Thr protein kinase family
	S6 kinase subfamily

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleolus

basic FUNCTION	ribosomal protein S6 kinase, serine/threonine kinase, non receptor type, involved in neuronal development
	can participate in non-growth factor signaling as for instance TP53-induced growth arrest (Duemmler 2005)
	its expression may limit the oncogenic, invasive, and metastatic potential of breast cancer cells (may be, in part, due to its regulation of claudin-2) (Thakur 2008)

CELLULAR PROCESS

protein, translation/synthesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule
	ATP

protein

RPS6

cell & other

REGULATION

Other

may be regulated by MYC

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in breast carcinoma constitutional   deletion     in complex X-linked mental retardation tumoral     --low   in colon carcinomas

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS