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FLASH GENE

Symbol

ANGPTL3

contributors: mct/npt/pgu - updated : 06-06-2016

HGNC name	angiopoietin-like 3
HGNC id	491

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

FHBL2

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   significantly increased podocyte motility, and dramatically increased the expression of nephrin tumoral     --over   in esophageal cancer tissues constitutional       loss of function does not affect the number of APOB-containing lipoproteins secreted by the liver but alters the particles that are made such that they are cleared more rapidly from the circulation via a noncanonical pathway(s) constitutional     --over   in glomerular podocytes of nephrotic syndrome constitutional       loss of function results in very low levels of LDL-cholesterol (C), HDL-C and triglyceride (TAG)

Susceptibility

atherosclerosis, coronary artery disease, diabetes mellitus

Variant & Polymorphism

Candidate gene
Marker	association of ANGPTL3 expression with the prognosis of subgroups of patients with esophageal cancer
Therapy target
	System Type Disorder Pubmed metabolism lipid cholesterol therapeutic antibodies that neutralize ANGPTL4 and ANGPTL3 may be useful for treatment of some forms of hyperlipidemia metabolism lipid   potential therapeutic target to treat combined hyperlipidemia, a major risk factor for atherosclerotic coronary heart disease

ANIMAL & CELL MODELS

KK obese mouse