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FLASH GENE
Symbol CLEC2D contributors: mct - updated : 07-05-2011
HGNC name C-type lectin domain family 2, member D
HGNC id 14351
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneB cell
Lymphoid/Immunedendritic cell Homo sapiens
Lymphoid/Immunenatural killer Homo sapiens
Lymphoid/ImmuneT cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • transmembrane domain near the N terminus
  • an extracellular domain similar to the carbohydrate recognition domain of C type lectin but without an intracellular ITIM, immunoreceptor, tyrosine based inhibitory motif
    • HOMOLOGY
    Homologene
    FAMILY
  • natural killer cell C-type lectins family
  • KLR family member
    • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • involved in mediating activation signals
  • novel regulator of bone remodeling
  • physiological negative regulator of bone
  • CLEC2D-stimulated IFN-gamma production in NK cells may involve post-transcriptional or translational events (
  • role for CLEC2D/KLRB1 in modulating immune responses to pathogens
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand for the NK cell inhibitory receptor, NKR-P1A (KLRB1)
  • ligand of KLRB1, found to be expressed on Toll-like receptor (TLR)-activated plasmacytoid and monocyte-derived dendritic cells (DC) and on activated B cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to reduction of bone mineral density in postmenopausal women
    Variant & Polymorphism other
  • women with a lysine (GG genotype) at position 19 displayed lower BMD at femoral neck and at lumbar spine sites than women having an asparagine residue
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS