Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GIGYF2 contributors: mct/npt - updated : 24-10-2016
HGNC name GRB10 interacting GYF protein 2
HGNC id 11960
ASSOCIATED DISORDERS
corresponding disease(s) PARK11
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
might contribute to the development of diabetes-associated cognitive disorder via negatively regulating IGF1R signaling pathway
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
diabete  
down-regulation of GIGYF2 expression may provide a potential novel approach to treat diabetes-associated cognitive impairment caused by aberrant IGF1R signaling pathway
ANIMAL & CELL MODELS
  • Heterozygous Gigyf2 +/- mice exhibits histopathological evidence of neurodegeneration such as motor dysfunction