Symbol
| GIGYF2
| contributors: mct/npt - updated : 24-10-2016
|
HGNC name
| GRB10 interacting GYF protein 2
|
HGNC id
| 11960
|
corresponding disease(s)
|
PARK11
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
constitutional
|  
|  
| --over
|  
|
might contribute to the development of diabetes-associated cognitive disorder via negatively regulating IGF1R signaling pathway | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
Therapy target
|
System | Type | Disorder | Pubmed |
diabete | | | |
down-regulation of GIGYF2 expression may provide a potential novel approach to treat diabetes-associated cognitive impairment caused by aberrant IGF1R signaling pathway |
| | | |
| Heterozygous Gigyf2 +/- mice exhibits histopathological evidence of neurodegeneration such as motor dysfunction |