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FLASH GENE
Symbol GIGYF2 contributors: mct/npt - updated : 24-10-2016
HGNC name GRB10 interacting GYF protein 2
HGNC id 11960
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a GYF domain, conserved eukaryotic adaptor domain that recognize proline-rich sequences, interact with the GRB10 proline-rich region, and bind AGO2
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may acting cooperatively with GRB10 to regulate receptor signaling
  • EIF4E2-GIGYF2 are a cofactor in translational repression and mRNA decay by ZFP36
  • upon tethering to a reporter mRNA, GIGYF2 exhibits strong, dose-dependent silencing activity, involving both mRNA destabilization and translational repression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • linked to IGF-I receptors by the GRB10 adapter protein following IGF-I stimulation
  • GIGYF2 directly interacts with EIF4E2, and this interaction is required for stabilization of both proteins
  • AGO2 interacting with GIGYF2 through the GYF domain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PARK11
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    might contribute to the development of diabetes-associated cognitive disorder via negatively regulating IGF1R signaling pathway
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabete  
    down-regulation of GIGYF2 expression may provide a potential novel approach to treat diabetes-associated cognitive impairment caused by aberrant IGF1R signaling pathway
    ANIMAL & CELL MODELS
  • Heterozygous Gigyf2 +/- mice exhibits histopathological evidence of neurodegeneration such as motor dysfunction