| Symbol
| HSPB1
| contributors: mct/pgu - updated : 09-05-2016
|
| HGNC name
| heat shock 27kDa protein 1
|
| HGNC id
| 5246
|
| corresponding disease(s)
|
CMT2F
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
| --over
|
| |
in gastric cancer | | constitutional
|
|
| --low
|
| |
in atherosclerotic plaques | | constitutional
|
|
| --over
|
| |
in acute coronary syndrome | | tumoral
|
|
| --over
|
|
is increased in chroni pancreatitis and pancreatic carcinoma  | | tumoral
|
|
| --over
|
| |
in angiogenic human breast cancer cells compared with nonangiogenic human breast cancer cells | | tumoral
|
|
| --low
|
| |
aberrant promoter hypermethylation of the HSPB1 gene may explain the reduced expression of HSPB1 noted in oral cancer cells | |
| Susceptibility
|
lower lymphocyte HSPB1 levels might be associated with an increased risk of lung cancer |
Variant & Polymorphism
| 
| |
| Candidate gene
| defects in these gene are cause of distal hereditary motor neuropathy |
|
expression of HSPB1 is an accurate and independent predictive biomarker of aggressive disease with a poor clinical outcome in prostate cancer without ETS-gene rearrangement |
|
potentail novel serum marker for the diagnosis of chronic obstructive pulmonary disease in the smoking population |
|
altered expression of this protein in testes showing abnormal spermatogenesis may be related to the pathogenesis of male infertility |
Marker
Therapy target
|
|
| System | Type | Disorder | Pubmed |
|---|
| cancer | | | |
| targeting HSPB1 might offer a useful strategy in cancer treatment | | neurology | neurodegenerative | | |
| . PEP1-HSPB1 fusion protein may be a potential therapeutic agent for familial amyotrophic lateral sclerosis patients | | cancer | digestive | colon | |
| may be a clinical target in patients with 5-FU-resistant colon cancer | | cancer | | | |
| target for interrupting signaling from membrane sex steroid receptors to tumor biology in hormone-responsive cancers |
| | |
|
| HspB1-deficient murine fibroblasts exhibit reduced entry into S phase and increased expression of cyclin-dependent kinase inhibitors p27(kip1) and p21(waf1) |