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FLASH GENE
Symbol TRHDE contributors: mct - updated : 25-08-2008
HGNC name thyrotropin-releasing hormone degrading enzyme
HGNC id 30748
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an extracellular C terminal domain
  • HEXXH+E motif, characteristic of a zinc dependent aminopeptidase
    • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • peptidase M1 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text integral membrane protein type II
    basic FUNCTION
  • involved in specific inactivation of TRH after its release
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    thyroid
    a component
  • protein constituent of membrane
  • homodimer, disulfide-linked
    • INTERACTION
    DNA
    RNA
    small molecule
    binds 1 zinc ion per subunit
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS