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FLASH GENE
Symbol TRHDE contributors: mct - updated : 25-08-2008
HGNC name thyrotropin-releasing hormone degrading enzyme
HGNC id 30748
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly
Respiratoryrespiratory tracttrachea  highly
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an extracellular C terminal domain
  • HEXXH+E motif, characteristic of a zinc dependent aminopeptidase
    • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • peptidase M1 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text integral membrane protein type II
    basic FUNCTION
  • involved in specific inactivation of TRH after its release
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    thyroid
    a component
  • protein constituent of membrane
  • homodimer, disulfide-linked
    • INTERACTION
    DNA
    RNA
    small molecule
    binds 1 zinc ion per subunit
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS