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FLASH GENE

Symbol

MATR3

contributors: mct - updated : 10-01-2018

HGNC name	matrin 3
HGNC id	6912

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES		acid
STRUCTURE

motifs/domains	an extensive acidic domain
	two RNA recognition motifs
	one matrin type zinc finger
	nuclear import and export motifs and several binding sites for DNA and RNA

HOMOLOGY

Homologene

FAMILY

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm
text	component of the nuclear matrix, which is a proteinaceous network that extends throughout the nucleus

basic FUNCTION	may play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network
	plays a significant role in controlling cell growth and proliferation, probably via formation of complexes with nuclear proteins that modulate pro- and antiapoptotic signaling pathways
	is a nuclear matrix protein involved in multiple nuclear processes
	role for MATR3, in the regulation of ZC3HAV1 antiretroviral activity, and suppressing MATR3 powers a heightened and broader ZC3HAV1 restriction of HIV-1 gene expression

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	component of the nuclear matrix, which is a proteinaceous network that extends throughout the nucleus
	integral component of nuclear matrix architecture implicated in interacting with other nuclear proteins and thus modulating the activity of proximal promoters

INTERACTION

DNA	several binding sites for DNA

RNA	nuclear import and export motifs and several binding sites for RNA

small molecule

protein	interact with SFPQ, and novel ATM target
	RNA-dependent interactions of RALY with MATR3, PABPC1 and ELAVL1
	function for MATR3 as a negative regulator of the ZC3HAV1-mediated restriction of retroviruses

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

MPD2

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   is responsible for reduced proliferation and leads to necrosis of endothelial cells

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS