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FLASH GENE
Symbol MATR3 contributors: mct - updated : 10-01-2018
HGNC name matrin 3
HGNC id 6912
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • an extensive acidic domain
  • two RNA recognition motifs
  • one matrin type zinc finger
  • nuclear import and export motifs and several binding sites for DNA and RNA
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    text component of the nuclear matrix, which is a proteinaceous network that extends throughout the nucleus
    basic FUNCTION
  • may play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network
  • plays a significant role in controlling cell growth and proliferation, probably via formation of complexes with nuclear proteins that modulate pro- and antiapoptotic signaling pathways
  • is a nuclear matrix protein involved in multiple nuclear processes
  • role for MATR3, in the regulation of ZC3HAV1 antiretroviral activity, and suppressing MATR3 powers a heightened and broader ZC3HAV1 restriction of HIV-1 gene expression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the nuclear matrix, which is a proteinaceous network that extends throughout the nucleus
  • integral component of nuclear matrix architecture implicated in interacting with other nuclear proteins and thus modulating the activity of proximal promoters
  • INTERACTION
    DNA several binding sites for DNA
    RNA nuclear import and export motifs and several binding sites for RNA
    small molecule
    protein
  • interact with SFPQ, and novel ATM target
  • RNA-dependent interactions of RALY with MATR3, PABPC1 and ELAVL1
  • function for MATR3 as a negative regulator of the ZC3HAV1-mediated restriction of retroviruses
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MPD2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    is responsible for reduced proliferation and leads to necrosis of endothelial cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS