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FLASH GENE

Symbol

TRAF6

contributors: mct/pgu - updated : 08-01-2019

HGNC name	TNF receptor-associated factor 6
HGNC id	12036

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	Traf6(-/-) mice display exencephaly and failure of neural tube closure
	TRAF6-deficient T cells exhibit hyperactivation of the phosphatidylinositol 3-kinase (PI3K)-Akt pathway and become resistant to suppression by CD4+ CD25+ regulatory T-cells