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| the serine/threonine kinase IRAK1 in response to IL1 mediated by the IL-1R pathway |
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mediating downstream of TRADD and TRAF2, the LMP1 (oncogenic latent membrane protein 1 of Epstein-Barr virus) signaling to p38 mitogen-activated protein kinase via a MAPK6 dependent pathway |
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interacting with UBE2N |
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interacting with TRAF4 and TICAM1 (silencer in TLR-mediated signaling) |
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activates the NFKB and MAPK cascades |
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MAPKBP1 interacted with not only NR2C2, but also with its upstream regulators, TNF-receptor associated factors 2 and 6 (TRAF2 and TRAF6)  |
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functions together with a ubiquitin-conjugating enzyme complex consisting of UBE2N and UBE2V1 to catalyse Lys 63-linked polyubiquitination, which activates the MAP3K7 kinase complex |
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OTUB1 and -2 interacted with TRAF3 and TRAF6, two E3 ubiquitin ligases required for virus-triggered IRF3 and NF-kappaB activation, respectively |
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NUMBL directly binds to TRAF6, and down-regulates TRAF6 protein level and shortens its half-life |
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important interaction between IKBKG and TRAF6 (a new binding site for TRAF6 located at the N-terminus of IKBKG and recognized by the coiled-coil domain of TRAF6) |
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NFKB1 activation by CSF2RB is dependent on TNFR-associated factor 6 (TRAF6) and association of TRAF6 with CSF2RB requires a consensus-binding motif found in other molecules known to interact with TRAF6 |
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stimulates the accumulation of insoluble and polyubiquitinated mutant PARK7 into cytoplasmic aggregates |
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binds SNCA and enhances its ubiquitination with atypical chains |
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essential for IL17A/TRAF3IP2-mediated activation of NFKB |
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interacts with and ubiquitinates WT and mutant HTT |
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RANBP9 participates in gene transcription by binding to TRAF6 |
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interacting with USP4 that is a deubiquitinase targeting TRAF2 and TRAF6 for deubiquitination |
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bound to TRAF6 and promoted K48-linked polyubiquitination, which led to the proteasomal degradation of TRAF6 |
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negative regulator of both endogenous as well as inducible expression of VEGFA in |
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physically interacts with Src family kinase (SFKs), and during this interaction, TRAF6 catalyzes Lys63-linked ubiquitination of SFKs that in turn reciprocally tyrosine phosphorylate TRAF6 in response to LPS |
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RNF8 interacts with UBE2N in a manner that is similar to that of the RING-type E3 ubiquitin ligase TRAF6 and the U-box-type E3 ubiquitin ligase, STUB1 |
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TRAF6, was critical for IL17A-induced TRAF3IP2 phosphorylation, and for IL17A-induced TBK1 activation, its association with TRAF3IP2, and consequent TRAF3IP2 phosphorylation |
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TRAF6 is a new STAT3 interactor |
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UBE2O is a novel negative regulator of TRAF6-dependent NFKB signaling |
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LAT plays an adapter role in TCR/CD28-induced activation of TRAF6 |
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physical association of TLR9, ICAM1 and TRAF6 leads to activation of noncanonical NFKB1 signalling |
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NUMBL could decrease the expression of TRAF6, CCND1, and MMP9 and increase the expression of CASP3 |
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PSEN1, PSEN2 are novel substrates for TRAF6-mediated K63-linked ubiquitination and ubiquitination of presenilins by TRAF6 increases presenilin holoprotein levels and reduced TRAF6 ubiquitination of presenilins results in reduction of calcium release from the endoplasmic reticulum |
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TRAF6 functions to upregulate HIF1A expression and promote tumor angiogenesis |
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OTUD7B regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination |
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TRAF6 is a binding partner of FHL2 and an important component of the Toll-like receptor-NFKB1 pathway |
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ITCH interacts with the deubiquitinating enzyme and is required for deubiquitination of TRAF6, thus limiting TNFSF11-induced osteoclast formation |
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WWP1 could degrade TRAF6, but not IRAK1, in the proteasome pathway |
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association of PINK1 with SARM1 and TRAF6 is an important step for mitophagy |
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SIK1 and SIK3 negatively regulate TLR4-mediated signaling through the interruption of TAB2-TRAF6 complex and thereby the inhibition of ubiquitination of TRAF6 |
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inhibits non-canonical TGFB1 signalling by recruiting the deubiquitinase TNFAIP3 to TRAF6 |
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TRAF6 mediates ubiquitination of the midbody ring localized protein KIF23/MKLP1 |
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TRAF5 negatively regulated the association of TAB2 with its signaling partner TRAF6 after TLR ligation in B cells |
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PPP1CC physically interacts with the E3 ubiquitin ligase TRAF6, and enhances the activity of TRAF6 towards itself and substrates such as IKBKG |
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plays a critical role in the regulation of macrophage homeostasis by inhibiting TRAF6-mediated AKT1 activation |
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role for TICAM2 in TLR4-mediated signaling in regulating inflammatory responses via its interaction with TRAF6, distinct from its role as a bridging adaptor between TLR4 and TICAM1 |
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ECSIT interacts with TRAF6, is ubiquitinated, and contributes to bactericidal activity during Toll-like receptor (TLR) signaling |
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TRAF6 is required for CSF2-induced ubiquitination and activation of AKT1 |
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TANK negatively regulates NFKB1 activation by DNA damage via inhibiting ubiquitination of TRAF6 |
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SQSTM1 is a critical regulator in CD40-mediated NFKB1 signaling via TRAF6 |
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BSG/CD147, a critical molecule for cancer cell invasion and metastasis, is a novel interacting partner of TRAF6 |
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VAV3 is a novel TRAF6 interaction partner that functions in the activation of cooperative signaling between TRAF6-binding sites (T6BSs) and the IVVY motif in the TNFRSF11A signaling complex |
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TRAF6-mediated degradation of DOK3 is required for production of IL6 and TNF in TLR9 signaling |
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YOD1 is a novel interactor of TRAF6 (antagonizes TRAF6/p62-dependent IL1 signaling to NFKB1) |
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TRAF6 is also required for the TNFSF13B-mediated activation of NFKB1 signal pathway |
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BCL3 interacts with TRAF6 through its ankyrin-repeat domain and inhibits osteoclastogenesis in bone marrow derived macrophages (BMDMs) |
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TRAF6 promotes TNFSF11-induced osteoclastogenesis by regulating novel non-canonical NFKB signaling via BCL3 deubiquitination |
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silencing METTL3 could sustain long-chain fatty acids (LCFAs) absorption through blocking the TRAF6-dependent inflammation response |
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function of TMUB1 as a novel modulator of TRAF6, regulating inflammatory responses driven by activation of the NFKB1 signaling pathway |
