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| PGC-1alpha null mice are lean and resistant to diet-induced obesity, constitutively activate gluconeogenic gene expression, and have elevated C/EBPbeta in liver  |
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transverse aortic constriction in mice lacking PGC-1alpha leads to accelerated cardiac dysfunction accompanied by signs of significant clinical heart failure |
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mice lacking PGC-1alpha show abnormal diurnal rhythms of activity, body temperature and metabolic rate |
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mice with combined deficiency of PGC-1alpha and PGC-1beta died shortly after birth with small hearts, bradycardia, intermittent heart block, and a markedly reduced cardiac output |
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impaired function of PGC-1alpha plays a critical role in muscle dysfunction in Huntington's disease transgenic mice |
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expression levels of PGC-1 alpha is significantly decreased in both Alzheimer's disease hippocampal tissues and AD-causing amyloid precursor protein mutant M17 cells |
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knockdown of PGC-1 alpha could exacerbate impaired mitochondrial biogenesis and mitochondrial deficits in AD-causing amyloid precursor protein mutant M17 cells |
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mice that lack cardiac PGC-1 alpha, a powerful regulator of angiogenesis, develop profound peripartum cardiomyopathy |