| 1 | LDHB, NRF1, PPARGC1A, TIGAR
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| TIGAR promotes neural stem cell differentiation through acetyl-CoA-mediated histone acetylation.
|
| Zhou W, Zhao T, Du J, Ji G, Li X, Ji S, Tian W, Wang X, Hao A.
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| Cell Death Dis 10(3):198. doi: 10.1038/s41419-019-1434-3. 2019
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| 2 | PPARGC1A, TEAD1, YAP1
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| YAP1-TEAD1 signaling controls angiogenesis and mitochondrial biogenesis through PGC1α.
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| Mammoto A, Muyleart M, Kadlec A, Gutterman D, Mammoto T.
|
| Microvasc Res 119:73-83. doi: 10.1016/j.mvr.2018.04.003. Epub 2018 Apr 20.
2018
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| 3 | MAPK7, PPARGC1A
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| Metabolic stress-induced cardiomyopathy is caused by mitochondrial dysfunction due to attenuated Erk5 signaling.
|
| Liu W, Ruiz-Velasco A, Wang S, Khan S, Zi M, Jungmann A, Dolores Camacho-Muñoz M, Guo J, Du G, Xie L, Oceandy D, Nicolaou A, Galli G, Müller OJ, Cartwright EJ, Ji Y, Wang X.
|
| Nat Commun 8(1):494. doi: 10.1038/s41467-017-00664-8.
2017
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| 4 | NDN, PPARGC1A
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| Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults.
|
| Hasegawa K, Yasuda T, Shiraishi C, Fujiwara K, Przedborski S, Mochizuki H, Yoshikawa K.
|
| Nat Commun 7:10943. doi: 10.1038/ncomms10943.
2016
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| 5 | FLCN, FNIP1, FNIP2, PPARGC1A
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| Birt-Hogg-Dubé syndrome: Clinical and molecular aspects of recently identified kidney cancer syndrome.
|
| Hasumi H, Baba M, Hasumi Y, Furuya M, Yao M.
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| Int J Urol. Mar;23(3):204-10. doi: 10.1111/iju.13015. Epub 2015 Nov 25. 2016
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| 6 | BHLHE40, PPARGC1A
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| Bhlhe40 Represses PGC-1α Activity on Metabolic Gene Promoters in Myogenic Cells.
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| Chung SY, Kao CH, Villarroya F, Chang HY, Chang HC, Hsiao SP, Liou GG, Chen SL.
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| Mol Cell Biol 35(14):2518-29. doi: 10.1128/MCB.00387-15. Epub 2015 May 11.
2015
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| 7 | IRF1, PPARGC1A
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| PGC-1α regulates the expression and activity of IRF-1.
|
| Lu H, Zhu L, Lian L, Chen M, Shi D, Wang K.
|
| IUBMB Life 67(4):300-5. doi: 10.1002/iub.1369. Epub 2015 Apr 15.
2015
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| 8 | PPARGC1A, TCHP
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| Decorin induces mitophagy in breast carcinoma cells via peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) and mitostatin.
|
| Neill T, Torres A, Buraschi S, Owens RT, Hoek JB, Baffa R, Iozzo RV.
|
| J Biol Chem 289(8):4952-68. doi: 10.1074/jbc.M113.512566. Epub 2014 Jan 8.
2014
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| 9 | BRAF, MITF, PPARGC1A
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| Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF.
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| Haq R, Shoag J, Andreu-Perez P, Yokoyama S, Edelman H, Rowe GC, Frederick DT, Hurley AD, Nellore A, Kung AL, Wargo JA, Song JS, Fisher DE, Arany Z, Widlund HR.
|
| Cancer Cell 23(3):302-15. doi: 10.1016/j.ccr.2013.02.003. Epub 2013 Mar 7.
2013
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| 10 | FNDC5, PPARGC1A
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| Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway.
|
| Wrann CD, White JP, Salogiannnis J, Laznik-Bogoslavski D, Wu J, Ma D, Lin JD, Greenberg ME, Spiegelman BM.
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| Cell Metab 18(5):649-59. doi: 10.1016/j.cmet.2013.09.008. Epub 2013 Oct 10.
2013
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| 11 | NQO1, PPARGC1A
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| The protein level of PGC-1α, a key metabolic regulator, is controlled by NADH-NQO1.
|
| Adamovich Y, Shlomai A, Tsvetkov P, Umansky KB, Reuven N, Estall JL, Spiegelman BM, Shaul Y.
|
| Mol Cell Biol. Jul;33(13):2603-13. doi: 10.1128/MCB.01672-12. Epub 2013 May 6. 2013
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| 12 | PPARGC1A, RNF34
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| RNF34 is a cold-regulated E3 ubiquitin ligase for PGC-1α and modulates brown fat cell metabolism.
|
| Wei P, Pan D, Mao C, Wang YX.
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| Mol Cell Biol 32(2):266-75. Epub 2011 Nov 7.
2012
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| 13 | NFE2L2, NRF1, PPARGC1A, TFAM
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| Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease.
|
| Sheng B, Wang X, Su B, Lee HG, Casadesus G, Perry G, Zhu X.
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| J Neurochem. 120(3):419-29 2012
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| 14 | PPARGC1A
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| Cardiac angiogenic imbalance leads to peripartum cardiomyopathy.
|
| Patten IS, Rana S, Shahul S, Rowe GC, Jang C, Liu L, Hacker MR, Rhee JS, Mitchell J, Mahmood F, Hess P, Farrell C, Koulisis N, Khankin EV, Burke SD, Tudorache I, Bauersachs J, del Monte F, Hilfiker-Kleiner D, Karumanchi SA, Arany Z.
|
| Nature. 485(7398):333-8. 2012
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| 15 | PPARGC1A, TFEB
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| PGC-1α rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function.
|
| Tsunemi T, Ashe TD, Morrison BE, Soriano KR, Au J, Roque RA, Lazarowski ER, Damian VA, Masliah E, La Spada AR.
|
| Sci Transl Med 4(142):142ra97.
2012
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| 16 | PPARGC1A
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| Skeletal muscle transcriptional coactivator PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restriction.
|
| Finley LW, Lee J, Souza A, Desquiret-Dumas V, Bullock K, Rowe GC, Procaccio V, Clish CB, Arany Z, Haigis MC.
|
| Proc Natl Acad Sci U S A 109(8):2931-6. doi: 10.1073/pnas.1115813109. Epub 2012 Feb 3.
2012
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| 17 | FNDC5, PPARA, PPARGC1A
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| A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis.
|
| Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Boström EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, Højlund K, Gygi SP, Spiegelman BM.
|
| Nature 481(7382):463-8. doi: 10.1038/nature10777.
2012
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| 18 | PPARGC1A
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| A greatly extended PPARGC1A genomic locus encodes several new brain-specific isoforms and influences Huntington disease age of onset.
|
| Soyal SM, Felder TK, Auer S, Hahne P, Oberkofler H, Witting A, Paulmichl M, Landwehrmeyer GB, Weydt P, Patsch W; European Huntington Disease Network.
|
| Hum Mol Genet 21(15):3461-73. doi: 10.1093/hmg/dds177. Epub 2012 May 15.
2012
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| 19 | PPARGC1A, SENP1
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| SUMO-specific protease 1 regulates mitochondrial biogenesis through PGC-1α.
|
| Cai R, Yu T, Huang C, Xia X, Liu X, Gu J, Xue S, Yeh ET, Cheng J.
|
| J Biol Chem 287(53):44464-70. doi: 10.1074/jbc.M112.422626. Epub 2012 Nov 14.
2012
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| 20 | ESRRA, PPARGC1A
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| Estrogen-related receptor α regulates osteoblast differentiation via Wnt/β-catenin signaling.
|
| Auld KL, Berasi SP, Liu Y, Cain M, Zhang Y, Huard C, Fukayama S, Zhang J, Choe S, Zhong W, Bhat BM, Bhat RA, Brown EL, Martinez RV.
|
| J Mol Endocrinol. 12;48(2):177-91. doi: 10.1530/JME-11-0140. Print 2012 Apr. 2012
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| 21 | PPARGC1A
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| PGC-1α, a key modulator of p53, promotes cell survival upon metabolic stress.
|
| Sen N, Satija YK, Das S.
|
| Mol Cell 44(4):621-34.
2011
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| 22 | PPARGC1A, PRKN, ZNF746
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| PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease.
|
| Shin JH, Ko HS, Kang H, Lee Y, Lee YI, Pletinkova O, Troconso JC, Dawson VL, Dawson TM.
|
| Cell 144(5):689-702. 2011
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| 23 | KSR1, PPARGC1A
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| Kinase suppressor of ras 1 (KSR1) regulates PGC1α and estrogen-related receptor α to promote oncogenic Ras-dependent anchorage-independent growth.
|
| Fisher KW, Das B, Kortum RL, Chaika OV, Lewis RE.
|
| Mol Cell Biol 31(12):2453-61. Epub 2011 Apr 25. 2011
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| 24 | PPARGC1A
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| Disorder-to-order transition underlies the structural basis for the assembly of a transcriptionally active PGC-1α/ERRγ complex.
|
| Devarakonda S, Gupta K, Chalmers MJ, Hunt JF, Griffin PR, Van Duyne GD, Spiegelman BM.
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| Proc Natl Acad Sci U S A 108(46):18678-83. Epub 2011 Nov 2.
2011
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| 25 | PPARGC1A
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| PGC1α promotes tumor growth by inducing gene expression programs supporting lipogenesis.
|
| Bhalla K, Hwang BJ, Dewi RE, Ou L, Twaddel W, Fang HB, Vafai SB, Vazquez F, Puigserver P, Boros L, Girnun GD.
|
| Cancer Res 71(21):6888-98. Epub 2011 Sep 13.
2011
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| 26 | PPARGC1A
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| Alternative splice variant PGC-1α-b is strongly induced by exercise in human skeletal muscle.
|
| Norrbom J, Sällstedt EK, Fischer H, Sundberg CJ, Rundqvist H, Gustafsson T.
|
| Am J Physiol Endocrinol Metab 301(6):E1092-8. Epub 2011 Aug 23.
2011
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| 27 | PPARGC1A
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| Peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC1alpha) is a metabolic regulator of intestinal epithelial cell fate.
|
| D'Errico I, Salvatore L, Murzilli S, Lo Sasso G, Latorre D, Martelli N, Egorova AV, Polishuck R, Madeyski-Bengtson K, Lelliott C, Vidal-Puig AJ, Seibel P, Villani G, Moschetta A.
|
| Proc Natl Acad Sci U S A 108(16):6603-8. Epub 2011 Apr 5.
2011
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| 28 | MTOR, PPARGC1A
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| Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function.
|
| Romanino K, Mazelin L, Albert V, Conjard-Duplany A, Lin S, Bentzinger CF, Handschin C, Puigserver P, Zorzato F, Schaeffer L, Gangloff YG, Rüegg MA.
|
| Proc Natl Acad Sci U S A 108(51):20808-13. doi: 10.1073/pnas.1111448109. Epub 2011 Dec 5.
2011
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| 29 | PPARGC1A, THG1L
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| IHG-1 promotes mitochondrial biogenesis by stabilizing PGC-1α. 2011 . PMID:
|
| Hickey FB, Corcoran JB, Docherty NG, Griffin B, Bhreathnach U, Furlong F, Martin F, Godson C, Murphy M.
|
| J Am Soc Nephrol. Aug;22(8):1475-85. doi: 10.1681/ASN.2010111154. Epub 2011 Jul 22 2011
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| 30 | ESRRA, PPARGC1A, PROX1
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| The homeobox protein Prox1 is a negative modulator of ERR{alpha}/PGC-1{alpha} bioenergetic functions.
|
| Charest-Marcotte A, Dufour CR, Wilson BJ, Tremblay AM, Eichner LJ, Arlow DH, Mootha VK, Giguère V.
|
| Genes Dev 24(6):537-42. Epub 2010 Mar 1.PMID: 20194433 2010
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| 31 | PPARGC1A
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| PGC-1 alpha accelerates cytosolic Ca2+ clearance without disturbing Ca2+ homeostasis in cardiac myocytes.
|
| Chen M, Wang Y, Qu A.
|
| Biochem Biophys Res Commun 396(4):894-900. Epub 2010 May 8.
2010
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| 32 | HD, PPARGC1A, TFAM
|
| Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease.
|
| Kim J, Moody JP, Edgerly CK, Bordiuk OL, Cormier K, Smith K, Beal MF, Ferrante RJ.
|
| Hum Mol Genet 19(20):3919-35. Epub 2010 Jul 21.
2010
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| 33 | EPAS1, PPARGC1A
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| PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types.
|
| Rasbach KA, Gupta RK, Ruas JL, Wu J, Naseri E, Estall JL, Spiegelman BM.
|
| Proc Natl Acad Sci U S A 107(50):21866-71. Epub 2010 Nov 24.
2010
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| 34 | PPARGC1A
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| Transcriptional coactivator PGC-1alpha promotes peroxisomal remodeling and biogenesis.
|
| Bagattin A, Hugendubler L, Mueller E.
|
| Proc Natl Acad Sci U S A 107(47):20376-81. Epub 2010 Nov 8.
2010
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| 35 | PPARGC1A, PPARGC1B
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| Peroxisome proliferator-activated receptor gamma coactivator 1alpha or 1beta overexpression inhibits muscle protein degradation, induction of ubiquitin ligases, and disuse atrophy.
|
| Brault JJ, Jespersen JG, Goldberg AL.
|
| J Biol Chem 285(25):19460-71. Epub 2010 Apr 19.
2010
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| 36 | PPARGC1A
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| PPAR-gamma coactivator-1alpha regulates progesterone production in ovarian granulosa cells with SF-1 and LRH-1.
|
| Yazawa T, Inaoka Y, Okada R, Mizutani T, Yamazaki Y, Usami Y, Kuribayashi M, Orisaka M, Umezawa A, Miyamoto K.
|
| Mol Endocrinol. 24(3):485-96. 2010
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| 37 | CIDEB, PPARGC1A
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| Peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) stimulates VLDL assembly through activation of cell death-inducing DFFA-like effector B (CideB).
|
| Chen Z, Norris JY, Finck BN.
|
| J Biol Chem 285(34):25996-6004. doi: 10.1074/jbc.M110.141598. Epub 2010 Jun 15.
2010
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| 38 | PPARGC1A
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| Identification and characterization of an alternative promoter of the human PGC-1alpha gene.
|
| Yoshioka T, Inagaki K, Noguchi T, Sakai M, Ogawa W, Hosooka T, Iguchi H, Watanabe E, Matsuki Y, Hiramatsu R, Kasuga M.
|
| Biochem Biophys Res Commun 381(4):537-43. Epub 2009 Feb 20.
2009
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| 39 | PPARGC1A, SIRT1
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| SIRT1 controls the transcription of the peroxisome proliferator-activated receptor-gamma Co-activator-1alpha (PGC-1alpha) gene in skeletal muscle through the PGC-1alpha autoregulatory loop and interaction with MyoD.
|
| Amat R, Planavila A, Chen SL, Iglesias R, Giralt M, Villarroya F.
|
| J Biol Chem 284(33):21872-80. Epub 2009 Jun 24.PMID: 19553684 2009
|
| 40 | PPARGC1A
|
| Alternative mRNA splicing produces a novel biologically active short isoform of PGC-1alpha.
|
| Zhang Y, Huypens P, Adamson AW, Chang JS, Henagan TM, Boudreau A, Lenard NR, Burk D, Klein J, Perwitz N, Shin J, Fasshauer M, Kralli A, Gettys TW.
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| J Biol Chem 284(47):32813-26. Epub 2009 Sep 22.PMID: 19773550 2009
|
| 41 | BCL3, ESRRA, PPARGC1A
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| Bcl3 interacts cooperatively with peroxisome proliferator-activated receptor gamma (PPARgamma) coactivator 1alpha to coactivate nuclear receptors estrogen-related receptor alpha and PPARalpha.
|
| Yang J, Williams RS, Kelly DP.
|
| Mol Cell Biol 29(15):4091-102. Epub 2009 May 18.PMID: 19451226 2009
|
| 42 | PPARGC1A, PPARGC1B
|
| PGC-1{alpha} and PGC-1{beta} regulate mitochondrial density in neurons.
|
| Wareski P, Vaarmann A, Choubey V, Safiulina D, Liiv J, Kuum M, Kaasik A.
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| J Biol Chem 284(32):21379-85. Epub 2009 Jun 19.
2009
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| 43 | PPARGC1A
|
| Impaired PGC-1alpha function in muscle in Huntington's disease.
|
| Chaturvedi RK, Adhihetty P, Shukla S, Hennessy T, Calingasan N, Yang L, Starkov A, Kiaei M, Cannella M, Sassone J, Ciammola A, Squitieri F, Beal MF.
|
| Hum Mol Genet. 18(16):3048-65 2009
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| 44 | PPARGC1A
|
| Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism.
|
| Choi CS, Befroy DE, Codella R, Kim S, Reznick RM, Hwang YJ, Liu ZX, Lee HY, Distefano A, Samuel VT, Zhang D, Cline GW, Handschin C, Lin J, Petersen KF, Spiegelman BM, Shulman GI.
|
| Proc Natl Acad Sci U S A 105(50):19926-31. Epub 2008 Dec 9.
2008
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| 45 | PPARGC1A
|
| SCFCdc4 acts antagonistically to the PGC-1alpha transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis.
|
| Olson BL, Hock MB, Ekholm-Reed S, Wohlschlegel JA, Dev KK, Kralli A, Reed SI.
|
| Genes Dev. 22(2):252-64. 2008
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| 46 | PPARGC1A
|
| Transcriptional coactivators PGC-1alpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart.
|
| Lai L, Leone TC, Zechner C, Schaeffer PJ, Kelly SM, Flanagan DP, Medeiros DM, Kovacs A, Kelly DP.
|
| Genes Dev. 22(14):1948-61. 2008
|
| 47 | CYP7A1, PPARGC1A
|
| Peroxisome proliferator-activated receptor-gamma coactivator-1alpha activation of CYP7A1 during food restriction and diabetes is still inhibited by small heterodimer partner.
|
| Shin DJ, Osborne TF.
|
| J Biol Chem 283(22):15089-96. doi: 10.1074/jbc.M710452200. Epub 2008 Apr 2.
2008
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| 48 | PPARGC1A
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| Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism.
|
| Liu C, Li S, Liu T, Borjigin J, Lin JD.
|
| Nature. 447(7143):477-81. 2007
|
| 49 | PPARGC1A, HTT
|
| Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.
|
| Cui L, Jeong H, Borovecki F, Parkhurst CN, Tanese N, Krainc D.
|
| Cell 127(1):59-69. 2006
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| 50 | PPARGC1A
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| PGC-1alpha, a New Therapeutic Target in Huntington's Disease?
|
| McGill JK, Beal MF.
|
| Cell 127(3):465-8. 2006
|
| 51 | PPARGC1A
|
| Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex
|
| Cooper MP, Qu L, Rohas LM, Lin J, Yang W, Erdjument-Bromage H, Tempst P, Spiegelman BM.
|
| Genes Dev. 20(21):2996-3009. 2006
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| 52 | PPARGC1A
|
| Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha.
|
| Arany Z, Novikov M, Chin S, Ma Y, Rosenzweig A, Spiegelman BM.
|
| Proc Natl Acad Sci U S A. 103(26):10086-91 2006
|
| 53 | PPARGC1A
|
| Transcriptional coactivator PGC-1alpha regulates chondrogenesis via association with Sox9.
|
| Kawakami Y, Tsuda M, Takahashi S, Taniguchi N, Esteban CR, Zemmyo M, Furumatsu T, Lotz M, Belmonte JC, Asahara H.
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| Proc Natl Acad Sci U S A 102(7):2414-9. Epub 2005 Feb 7. 2005
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| 54 | PPARGC1A, SIRT1
|
| Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.
|
| Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P.
|
| Nature 434(7029):113-8. 2005
|
| 55 | PPARGC1A, SIRT1
|
| SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}.
|
| Nemoto S, Fergusson MM, Finkel T.
|
| J Biol Chem 280(16):16456-60. Epub 2005 Feb 16. 2005
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| 56 | PPARGC1A
|
| Haplotypes of PPARGC1A are associated with glucose tolerance, body mass index and insulin sensitivity in offspring of patients with type 2 diabetes.
|
| Pihlajamaki J, Kinnunen M, Ruotsalainen E, Salmenniemi U, Vauhkonen I, Kuulasmaa T, Kainulainen S, Laakso M.
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| Diabetologia 48(7):1331-4. Epub 2005 May 24. 2005
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| 57 | PPARA, PPARGC1A, TRIB3
|
| PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3.
|
| Koo SH, Satoh H, Herzig S, Lee CH, Hedrick S, Kulkarni R, Evans RM, Olefsky J, Montminy M.
|
| Nat Med 10(5):530-4. Epub 2004 Apr 25. 2004
|
| 58 | PPARGC1A
|
| Complex haplotypes of the PGC-1alpha gene are associated with carbohydrate metabolism and type 2 diabetes.
|
| Oberkofler H, Linnemayr V, Weitgasser R, Klein K, Xie M, Iglseder B, Krempler F, Paulweber B, Patsch W.
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| Diabetes 53(5):1385-93. 2004
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| 59 | PPARGC1A
|
| Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1alpha. Functional implications in hepatic cholesterol and glucose metabolism.
|
| Bhalla S, Ozalp C, Fang S, Xiang L, Kemper JK.
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| J Biol Chem. 279(43):45139-47. 2004
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| 60 | PPARGC1A
|
| Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice.
|
| Lin J, Wu PH, Tarr PT, Lindenberg KS, St-Pierre J, Zhang CY, Mootha VK, Jäger S, Vianna CR, Reznick RM, Cui L, Manieri M, Donovan MX, Wu Z, Cooper MP, Fan MC, Rohas LM, Zavacki AM, Cinti S, Shulman GI, Lowell BB, Krainc D, Spiegelman BM.
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| Cell. 119(1):121-35. 2004
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| 61 | PRDX6, PPARGC1A
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| PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes.
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| Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, Lehar J, Puigserver P, Carlsson E, Ridderstrale M, Laurila E, Houstis N, Daly MJ, Patterson N, Mesirov JP, Golub TR, Tamayo P, Spiegelman B, Lander ES, Hirschhorn JN, Altshuler D, Groop LC.
|
| Nat Genet 34(3):267-73. 2003
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| 62 | PPARGC1A
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| Upstream stimulatory factor represses the induction of carnitine palmitoyltransferase-Ibeta expression by PGC-1.
|
| Moore ML, Park EA, McMillin JB.
|
| J Biol Chem. 278(19):17263-8. 2003
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| 63 | CAMK4, PPARGC1A, PPARGC1B
|
| Regulation of mitochondrial biogenesis in skeletal muscle by CaMK.
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| Wu H, Kanatous SB, Thurmond FA, Gallardo T, Isotani E, Bassel-Duby R, Williams RS.
|
| Science 296(5566):349-52. 2002
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| 64 | PPARGC1A, PPARGC1B
|
| A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes.
|
| Hara K, Tobe K, Okada T, Kadowaki H, Akanuma Y, Ito C, Kimura S, Kadowaki T.
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| Diabetologia 45(5):740-3. Epub 2002 Apr 23. 2002
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| 65 | PPARGC1A
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| PGC-1 functions as a transcriptional coactivator for the retinoid X receptors.
|
| Delerive P, Wu Y, Burris TP, Chin WW, Suen CS.
|
| J Biol Chem. 277(6):3913-7. 2002
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| 66 | PPARGC1A
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| PGC-1 and PERC, coactivators of the estrogen receptor-related receptor gamma.
|
| Hentschke M, Süsens U, Borgmeyer U.
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| Biochem Biophys Res Commun. 299(5):872-9. 2002
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| 67 | PPARGC1A, PPARGC1B
|
| Regulation of the transcriptional coactivator PGC-1 via MAPK-sensitive interaction with a repressor.
|
| Knutti D, Kressler D, Kralli A.
|
| Proc Natl Acad Sci U S A 98(17):9713-8. 2001
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| 68 | PPARGC1A, PPARGC1B
|
| Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1.
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| Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, Newgard CB, Spiegelman BM.
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| Nature 413(6852):131-8. 2001
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| 69 | CREB1, PPARGC1A, PPARGC1B
|
| CREB regulates hepatic gluconeogenesis through the coactivator PGC-1.
|
| Herzig S, Long F, Jhala US, Hedrick S, Quinn R, Bauer A, Rudolph D, Schutz G, Yoon C, Puigserver P, Spiegelman B, Montminy M.
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| Nature 413(6852):179-83. 2001
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| 70 | PPARGC1A
|
| Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1.
|
| Puigserver P, Rhee J, Lin J, Wu Z, Yoon JC, Zhang CY, Krauss S, Mootha VK, Lowell BB, Spiegelman BM.
|
| Mol Cell. 8(5):971-82. 2001
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| 71 | PPARGC1A, PPARGC1B
|
| Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis.
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