basic FUNCTION
| promoting insulin resistance in liver through PPARA-dependent induction of TRIB3 |
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playing an important role in energy metabolism by co-ordinating transcription programmes of mitochondrial biogenesis, adaptive thermogenesis and fatty-acid beta-oxydation |
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stimulates mitochondrial biogenesis and respiration in muscle cells through an induction of uncoupling protein 2 and through regulation of the nuclear respiratory factors |
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plays a key role in the transcriptional control of genes encoding mitochondrial fatty acid beta-oxidation enzymes |
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a coactivator of PPARalpha in the transcriptional control of mitochondrial FAO capacity |
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a key modulator of hepatic gluconeogenesis and as a central target of the insulin-cAMP axis in liver |
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a bona fide coactivator for RXRalpha |
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also coactivating transcription factor for gluco-neogenesis in liver and glucose uptake in muscle |
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may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity |
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can regulate the activities of cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs) |
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activating and determining specificity of PPAR subtypes |
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activating transcription trhough glucocorticoid receptors |
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activating liver recpetors N1RH2, N1RH3 |
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regulating SOX9-dependent chondrogenesis in mesenchymal stem cells and chondrocytes |
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have a key role in the control of energy metabolism in the early stages of Huntington's disease pathogenesis |
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stimulates the expression of clock genes, notably Bmal1 and Rev-erbalpha , through coactivation of the ROR family of orphan nuclear receptors |
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a key component of the circadian oscillator that integrates the mammalian clock and energy metabolism |
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necessary for the postnatal metabolic and functional maturation of heart and brown adipose tissue |
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controls mitochondrial biogenesis and energy homeostasis |
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PPARGC1A and PPARGC1B control mitochondrial capacity in an additive and independent manner |
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its central function in many cellular contexts and in particular in brown adipocytes is to promote mitochondrial biogenesis |
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multi-functional coactivator that is involved in the regulation of cardiac mitochondrial functional capacity and cellular energy metabolism |
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can ameliorate cardiac Ca2+ cycling and improve cardiac work output in response to physiological stress |
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plays a key role in decreasing cellular Ca2+-overload, reorganizing cardiac function and improving cardiac adaptability |
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capacity of PPARGC1A and PPARGC1B to inhibit FOXO3 and NFkappaB actions and proteolysis, which helps explain how exercise prevents muscle atrophy |
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critical to peroxisomal physiology, establishing a role for this factor as a fundamental orchestrator of cellular adaptation to energy demands |
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EPAS1 acts downstream of PPARGC1A as a key regulator of a muscle fiber-type program and the adaptive response to exercise |
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regulates enterocyte cell fate and protects against tumorigenesis |
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ability to promote anchorage-independent growth required interaction with ESRRA, and treatment with an inhibitor of ESRRA impeded anchorage-independent growth |
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PPARGC1A, and PPARGC1B modulate mitochondrial biogenesis and energy homeostasis |
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coordinately regulates mitochondrial and fatty acid metabolism to promote tumor growth |
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role in regulating TP53-mediated cell fate decisions in response to metabolic stress |
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stimulates the expression of several muscle gene products that are potentially secreted, including FNDC5 |
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required for the induction of the mitochondrial transcriptional program and the increase in mitochondrial density observed during calorie restriction |
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skeletal muscle PPRGC1A is required for the mitochondrial, but not the metabolic, response to calorie restriction |
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implicated in the pathogenesis of neurodegenerative disorders (Huntington disease) |
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promoted HTT turnover and the elimination of protein aggregates by activating TFEB, a master regulator of the autophagy-lysosome pathway |
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SUMOylation of PPARGC1A controlled by SENP1 plays an important role in mitochondrial biogenesis and function |