| basic FUNCTION
| vascular ligand for integrin receptors playing in vascular development and remodeling, in regulating angiogenesis and endothelial cell function, antagonizing VEGF signaling in endothelial cells, as well as enhanced their expression of the antiangiogenic factor, thrombospondin-1 |
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promoting adhesion of endothelial cells through interaction of integrins and the RGD motif  |
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essential for elastic fibre development |
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calcium-dependent elastin-binding protein that scaffolding cells to elastic fibers, there by preventing elastinopathy in the skin, lung, and vasculature |
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integrin-binding extracellular matrix protein that mediates endothelial cell adhesion and scaffolds cells to elastic fibers |
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function as angiogenesis inhibitors and suppress tumor growth |
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acting as a bridging peptide between elastin fibers and cell surface integrins in blood vessel wall |
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extracellular matrix glycoprotein that participates in elastogenesis |
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may promote extracellular deposit formation in macular degeneration |
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potently induces elastic fiber assembly and maturation by organizing tropoelastin and cross-linking enzymes onto microfibrils |
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enhances elastic fiber formation in part by improving the self-association properties of tropoelastin (ELN) |
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distinct roles of EFEMP2 and FBLN5 in elastic fiber assembly and how they act in concert to chaperone cross-linked elastin onto microfibrils |
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FBLN2 and FBLN5 cooperatively function to form the internal elastic lamina during postnatal development by directing the assembly of elastic fibers, and are responsible for maintenance of the adult vessel wall after injury |
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dual role of FBLN5 in human placental development |
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integrin-binding matricellular protein that is essential for elastic fiber assembly, regulated the activity of MMP9 to maintain integrity of the vaginal wall and prevented development of Pelvic organ prolapse (POP) |
