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FLASH GENE

Symbol

AP2A1

contributors: - updated : 01-06-2006

HGNC name	adaptor-related protein complex 2, alpha 1 subunit
HGNC id	561

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive salivary gland         Nervous brain           brain hindbrain cerebellum       spinal cord

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular     Muscular striatum skeletal     Nervous central

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text

forebrain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to murine Ap2a1 (98.5pc)

Homologene

FAMILY

adaptor complexes large subunits family

CATEGORY

adaptor , transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic,vesicle
text	endocytic coated vesicles

basic FUNCTION

AP2 adaptor complex linking clathrin to receptors in coated vesicles, clathrin-associated protein complexes are believed to interact with cytoplasmic domains of transmembrane proteins leading to their selection and concentration

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

endocytosis transport , cellular trafficking transport

PATHWAY

metabolism

signaling

a component

subunit of AP-2 adaptor complex, clathrin coat assembly complex

INTERACTION

DNA

RNA

small molecule

protein

HIP1

cell & other

REGULATION

activated by

the autonomous E1A,requiring derepression of AP2A promoter by interaction of E1A with KLF12 corepressor CTBP1

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS